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Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00627133
Recruitment Status : Withdrawn
First Posted : February 29, 2008
Last Update Posted : June 7, 2018
Sponsor:
Collaborator:
UCB Pharma
Information provided by:
Medical University of South Carolina

Brief Summary:
Pilot study to evaluate efficacy of Keppra (levetiracetam) for seizure control in patients with alcohol related seizures.

Condition or disease Intervention/treatment Phase
Seizure, Alcohol Related Drug: levetiracetam Phase 2

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Pilot Study Examining the Efficacy of Keppra in Acute Alcohol Related Seizure Control in the Emergency Department Setting
Study Start Date : February 2008
Actual Primary Completion Date : February 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Seizures

Arm Intervention/treatment
Experimental: 1 Drug: levetiracetam
2 gram iv load, 500mg bid




Primary Outcome Measures :
  1. Decreased seizures [ Time Frame: 1, 2, 4, 8 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • No trauma
  • Not pregnant
  • No other cause for seizure (hypoglycemia, CNS causes, trauma)
  • Good family support
  • Working telephone contact

Exclusion Criteria:

  • Pregnancy
  • Renal failure (creatine > 2mg/dl
  • Fever or illness
  • Hypotension
  • Any trauma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00627133


Locations
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United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Sponsors and Collaborators
Medical University of South Carolina
UCB Pharma
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Responsible Party: Keith Borg MD PhD, Medical University of South Carolina
ClinicalTrials.gov Identifier: NCT00627133    
Other Study ID Numbers: K17644
First Posted: February 29, 2008    Key Record Dates
Last Update Posted: June 7, 2018
Last Verified: February 2008
Keywords provided by Medical University of South Carolina:
Alcohol seizure
Additional relevant MeSH terms:
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Seizures
Alcohol Withdrawal Seizures
Neurologic Manifestations
Nervous System Diseases
Alcohol-Induced Disorders, Nervous System
Neurotoxicity Syndromes
Poisoning
Chemically-Induced Disorders
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Substance Withdrawal Syndrome
Levetiracetam
Anticonvulsants
Nootropic Agents