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Aortic Dimensions in Turner Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00624949
Recruitment Status : Unknown
Verified February 2008 by University of Aarhus.
Recruitment status was:  Active, not recruiting
First Posted : February 28, 2008
Last Update Posted : February 28, 2008
Information provided by:
University of Aarhus

Brief Summary:
An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Condition or disease
Turner Syndrome

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Study Type : Observational
Actual Enrollment : 102 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.
Study Start Date : August 2003
Estimated Primary Completion Date : June 2012
Estimated Study Completion Date : June 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Turner Syndrome

women with Turner syndrome
Control women

Primary Outcome Measures :
  1. Aortic diameter at 3 well-defined levels measured by MRI and ECHO [ Time Frame: 2-yearly for 6 years ]

Secondary Outcome Measures :
  1. 24hour ambulatory blood pressure [ Time Frame: 24h 2-yearly for 6 years ]

Biospecimen Retention:   Samples With DNA
Blood samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Recrutted from hospital clinics and through the patient organisation

Inclusion Criteria:

  • Turner syndrome
  • Age 18-70 years

Exclusion Criteria:

  • Extreme adipositas
  • Contraindications to a MRI scan
  • Malignant disease

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Professor Jens Sandahl Christiansen, Aarhus University Hospital, Aarhus, Denmark Identifier: NCT00624949    
Other Study ID Numbers: 20010248
First Posted: February 28, 2008    Key Record Dates
Last Update Posted: February 28, 2008
Last Verified: February 2008
Keywords provided by University of Aarhus:
Turner syndrome
aortic dimensions
blood pressure
aortic dilatation
aortic rupture
Additional relevant MeSH terms:
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Turner Syndrome
Gonadal Dysgenesis
Pathologic Processes
Disorders of Sex Development
Urogenital Abnormalities
Sex Chromosome Disorders of Sex Development
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Congenital Abnormalities
Sex Chromosome Disorders
Chromosome Disorders
Genetic Diseases, Inborn
Gonadal Disorders
Endocrine System Diseases