COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00616746
Recruitment Status : Completed
First Posted : February 15, 2008
Last Update Posted : July 8, 2014
VA Connecticut Healthcare System
Information provided by (Responsible Party):
Yale University

Brief Summary:
The purpose of this study is to characterize the interactive effects of acute intravenous (IV) alcohol and nicotine administration in male and female smokers and nonsmokers who use alcohol.

Condition or disease Intervention/treatment Phase
Alcohol Consumption Tobacco Use Drug: Nicotine Drug: Ethanol Early Phase 1

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Intervention Model: Single Group Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Official Title: Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans
Study Start Date : January 2007
Actual Primary Completion Date : June 2010
Actual Study Completion Date : June 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
Three test days, within-subject design.
Drug: Nicotine
1.0 microg/kg/min IV x 10 minutes

Drug: Ethanol

Primary Outcome Measures :
  1. Behavioral and Cognitive Measures [ Time Frame: Baseline and Test Day ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male or Female, 21 to 50 years old.

Exclusion Criteria:

  • Alcohol or Nicotine Naive

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00616746

Layout table for location information
United States, Connecticut
VA Connecticut Healthcare System, West Haven Campus
West Haven, Connecticut, United States, 06516
Sponsors and Collaborators
Yale University
VA Connecticut Healthcare System
Layout table for investigator information
Principal Investigator: Deepak C D'Souza, M.D. Yale University

Layout table for additonal information
Responsible Party: Yale University Identifier: NCT00616746    
Other Study ID Numbers: 0607001614
First Posted: February 15, 2008    Key Record Dates
Last Update Posted: July 8, 2014
Last Verified: July 2014
Keywords provided by Yale University:
Alcohol, nicotine
Additional relevant MeSH terms:
Layout table for MeSH terms
Alcohol Drinking
Drinking Behavior
Anti-Infective Agents, Local
Anti-Infective Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Ganglionic Stimulants
Autonomic Agents
Peripheral Nervous System Agents
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action