Clonidine to Prevent Implantable Cardiovertor Defibrillator Firing
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ClinicalTrials.gov Identifier: NCT00585871 |
Recruitment Status :
Withdrawn
(could not recruit)
First Posted : January 3, 2008
Last Update Posted : July 24, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Ventricular Tachycardia | Drug: clonidine Drug: metoprolol | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 0 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Treatment |
Official Title: | Clonidine to Prevent Implantable Cardiovertor Defibrillator Firing |
Actual Study Start Date : | May 2006 |
Actual Primary Completion Date : | January 2012 |
Actual Study Completion Date : | January 2012 |

Arm | Intervention/treatment |
---|---|
Experimental: Clonidine therapy group
clonidine 0.1 TID
|
Drug: clonidine
0.1 mg tid |
Active Comparator: Metoprolol control group
metoprolol 25 TID
|
Drug: metoprolol
25 mg tid |
- episodes of non-sustained ventricular tachycardia [ Time Frame: one year ]
- defibrillator shocks [ Time Frame: one year ]

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Ages Eligible for Study: | 18 Years to 85 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Implantable defibrillator treated patients with 5 episodes of ventricular tachycardia per 3 month period
Exclusion Criteria:
- No more than one shock/3 months
- No contraindication to clonidine
- Non-compliance
- Asthma

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00585871
United States, Iowa | |
UIHC | |
Iowa City, Iowa, United States, 52242 |
Principal Investigator: | james b martins, md | University of Iowa |
Responsible Party: | James Martins, Professor, University of Iowa |
ClinicalTrials.gov Identifier: | NCT00585871 History of Changes |
Other Study ID Numbers: |
200602703 study is over no ID is needed |
First Posted: | January 3, 2008 Key Record Dates |
Last Update Posted: | July 24, 2018 |
Last Verified: | July 2018 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Keywords provided by James Martins, University of Iowa:
ICD patients with 5 VTs per 3 month period |
Additional relevant MeSH terms:
Clonidine Tachycardia Tachycardia, Ventricular Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes Metoprolol Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antihypertensive Agents |
Sympatholytics Autonomic Agents Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Anti-Arrhythmia Agents Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Antagonists Adrenergic Antagonists |