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Genetic Studies in Breast Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00582322
Recruitment Status : Completed
First Posted : December 28, 2007
Last Update Posted : July 20, 2009
Information provided by:
Memorial Sloan Kettering Cancer Center

Brief Summary:
The purpose of this study is to determine the specific genetic alterations associated with breast cancer. This will leat to a better understanding of the genetic causes of breast cancer.

Condition or disease
Breast Cancer Ovarian Cancer

Detailed Description:
It is estimated that 175,000 new breast cancer cases and 44,5000 cancer deaths will result from female breast cancer in 1991. One of the most important risk factors is a family history of breast cancer. A susceptibility allele which accounts for a large proportion of familial breast cancer has been localized to chromosome 17q and attempts to clone the susceptibility are proceeding rapidly. The existence of recognized susceptibility loci and the awareness of a significan proportion of genetic predisposition and the associated penetrances remain unknown and are impossible to estimate without bias from previous studies. This study is designed to estimate heterogeniety and prenetrance in a series of unslected families, identify additional breast cancer susceptibility locs, as well as provide resources for gene isolation and mutation analysis studies.

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Study Type : Observational
Actual Enrollment : 483 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Genetic Studies in Breast Cancer
Study Start Date : February 1992
Actual Primary Completion Date : July 2009
Actual Study Completion Date : July 2009

Biospecimen Retention:   Samples With DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with breast cancer seen at MSKCC and healthy family members.

Inclusion Criteria:

  • patient with breast cancer under age 41
  • patient with bilateral breast cancer 41-50 years old or 41-50 years old with a first degree relative (mother, sister, daughter) with breast cancer diagnosed under age 50
  • patient with ovarian cancer with first degree relative with either ovarian cancer diagnosed at any age or breast cancer diagnosed under age 60
  • patient any age with either ovarian or breast cancer who have 2 first degree rleatives with either ovarian cancer diagnosed at any age or breast cancer diagnosed under age 50
  • relatives of any of the above patients will be included in this trial if a genetic abnormality is found in the patient's blood sample

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00582322

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United States, New York
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065
Sponsors and Collaborators
Memorial Sloan Kettering Cancer Center
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Principal Investigator: Teresa Gilewski, MD Memorial Sloan Kettering Cancer Center
Additional Information:
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Responsible Party: Teresa Gilewski, MD, Memorial Sloan-Kettering Cancer Center Identifier: NCT00582322    
Other Study ID Numbers: 92-007
First Posted: December 28, 2007    Key Record Dates
Last Update Posted: July 20, 2009
Last Verified: July 2009
Keywords provided by Memorial Sloan Kettering Cancer Center:
Breast Cancer
Ovarian Cancer
Family History
Genetic Studies
Additional relevant MeSH terms:
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Breast Neoplasms
Ovarian Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Endocrine Gland Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders