COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00563888
Recruitment Status : Unknown
Verified November 2007 by University of Konstanz.
Recruitment status was:  Active, not recruiting
First Posted : November 26, 2007
Last Update Posted : November 26, 2007
German Research Foundation
Information provided by:
University of Konstanz

Brief Summary:
Effective Treatment of PTSD involves talking about the traumatic event in detail.It is unclear how this process influences the sensory-specific trauma network (fear structure)in the traumatized person. The goal of the project is to test the hypothesis that treatment-facilitated recovery does not change the original fear structure but establishes an inhibitory mechanism that depends on verbal activity. An affective visual steady-state paradigm in magnetencephalography (MEG) using positive, aversive and neutral picture stimuli will be used to examine the spatial and temporal pattern of the processing of emotional stimuli. To examine the effects of treatment this paradigm will be used as outcome measure within a randomized controlled trial of Narrative Exposure Therapy and a waiting-list control condition for severely traumatized torture victims.

Condition or disease Intervention/treatment Phase
PTSD Behavioral: NET Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims
Study Start Date : January 2007
Estimated Study Completion Date : December 2008

Arm Intervention/treatment
Experimental: A
Narrative Exposure Therapy (NET)
Behavioral: NET
Narrative Exposure Therapy for traumatized survivors of organized violence

No Intervention: B
Waitinglist Control Group

Primary Outcome Measures :
  1. PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS) [ Time Frame: 4 & 9 months after completion of treatment ]

Secondary Outcome Measures :
  1. steady state visual evoked magnetic fields in response to affective stimuli [ Time Frame: 4 & 9 months after completion of treatment ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • experiences of organized violence/torture
  • PTSD diagnosis

Exclusion Criteria:

  • psychotic disorder
  • neurological disease or seizures
  • current drug/alcohol abuse

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00563888

Layout table for location information
University of Konstanz, Department of Psychology
Konstanz, Germany, 78467
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Layout table for investigator information
Study Director: Claudia Catani, Dr. University of Konstanz
Principal Investigator: Frank Neuner, Prof. University of Konstanz
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00563888    
Other Study ID Numbers: SOSS-B6
First Posted: November 26, 2007    Key Record Dates
Last Update Posted: November 26, 2007
Last Verified: November 2007
Keywords provided by University of Konstanz:
torture survivors
Narrative Exposure Therapy
trauma-related memory processes
steady state visual evoked fields
Additional relevant MeSH terms:
Layout table for MeSH terms
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Trauma and Stressor Related Disorders
Mental Disorders