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Endothelial Progenitor Cells and Pulmonary Idiopathic Arterial Hypertension

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ClinicalTrials.gov Identifier: NCT00551408
Recruitment Status : Completed
First Posted : October 31, 2007
Last Update Posted : October 16, 2018
Sponsor:
Information provided by (Responsible Party):
Dr. Carlos jerjes-Sanchez Diaz, Unidad de Investigacion Clinica en Medicina S.C.

Brief Summary:

Endothelial dysfunction ultimately represents an imbalance between the magnitude of injury and the capacity for repair.

Current evidence established that endothelial progenitor cells (EPC) participate in several models of vascular disease as acute coronary syndromes, stroke, diabetes, peripheral artery disease, etc. However EPC in the setting of PAH is less well established. The target of this study is to demonstrate if the number of EPC is increased in a mexican population of patients with PAH.


Condition or disease
Pulmonary Idiopathic Arterial Hypertension

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Determination of Endothelial Progenitor Cells in Pulmonary Idiopathic Arterial Hypertension.
Study Start Date : August 2007
Actual Primary Completion Date : July 2008
Actual Study Completion Date : October 2016

Resource links provided by the National Library of Medicine


Group/Cohort
A
20 patients with idiopathic pulmonary arterial hypertension in the WHO functional class II to III, and had a mean pulmonary artery pressure >30 mm Hg on right heart catheterization able to walk >50 m during a standardized 6-min walk test.



Biospecimen Retention:   Samples With DNA
whole blood.


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with IPAH between 18 and 70 years of age of either gender were invited to participate in the study
Criteria

Inclusion Criteria:

  • Patients were included in the study if they were in The WHO functional class II to III, and had a mean pulmonary artery pressure >30 mm Hg on right heart catheterization. The ability to walk >50 m during a standardized 6-min walk test.

Exclusion Criteria:

  • Pulmonary hypertension as a result of heart disease, pulmonary disease, sleep-associated disorders, chronic thromboembolic disease, autoimmune or collagen vascular disease, HIV infection, liver disease, major bleeding requiring blood transfusion,renal dysfunction, and evidence for malignant diseases were excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00551408


Locations
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Mexico
Unidad de Investigacion Clinica en Medicina SC.
Monterrey, Nuevo Leon, Mexico, 64020
Sponsors and Collaborators
Unidad de Investigacion Clinica en Medicina S.C.
Investigators
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Principal Investigator: Carlos J Sanchez Diaz, MD. Unidad de Investigacion Clinica en Medicina SC.

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Responsible Party: Dr. Carlos jerjes-Sanchez Diaz, Principal investigator, Unidad de Investigacion Clinica en Medicina S.C.
ClinicalTrials.gov Identifier: NCT00551408     History of Changes
Other Study ID Numbers: UDICEM07-012
07-012
First Posted: October 31, 2007    Key Record Dates
Last Update Posted: October 16, 2018
Last Verified: October 2018
Additional relevant MeSH terms:
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Hypertension
Vascular Diseases
Cardiovascular Diseases