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Trial record 9 of 12 for:    gemcitabine and gleevec

A Phase II Study of the Association of Glivec® Plus Gemzar® in Patients With Unresectable, Refractory, Malignant Mesothelioma

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ClinicalTrials.gov Identifier: NCT00551252
Recruitment Status : Unknown
Verified October 2007 by Gruppo Italiano MEsotelioma.
Recruitment status was:  Not yet recruiting
First Posted : October 30, 2007
Last Update Posted : October 30, 2007
Information provided by:
Gruppo Italiano MEsotelioma

Brief Summary:
The purpose of this study is to evaluate the antitumor activity of a combination of Imatinib mesylate and Gemcitabine in patients with unresectable malignant mesothelioma expressing either PDGFR-beta or C-kit

Condition or disease Intervention/treatment Phase
Mesothelioma Drug: Imatinib mesylate plus Gemcitabine Phase 2

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 56 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase II Study of the Association of Glivec® (Imatinib Mesylate, Formerly Known as STI 571) Plus Gemzar® (Gemcitabine) in Patients With Unresectable, Refractory, Malignant Mesothelioma Expressing Either PDGFR-Beta or C-Kit
Study Start Date : January 2008
Estimated Study Completion Date : December 2009

Arm Intervention/treatment
Experimental: I Drug: Imatinib mesylate plus Gemcitabine
Imatinib (400 mg daily) + Gemcitabine (500 mg/sqm, days 1 and 8 every 21 days) for a maximum of 6 cycles

Primary Outcome Measures :
  1. Overall response rate [ Time Frame: Every two months ]

Secondary Outcome Measures :
  1. Progression-free-survival; Overall Survival; Safety [ Time Frame: Follow-up after end of treatment will be every three months; safety will be analyzed throughout the whole study ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age of > 18 years and < 72 years
  • Patients with a histologically proven malignant mesothelioma of the pleura or of the peritoneum, expressing either PDFGR-beta or C-Kit by immunochemistry (ICH)
  • Locally advanced disease, unsuitable for curative surgical resection, or metastatic disease
  • Confirmed progression of the disease according to modified REcist-criteria, documented after a first-line, systemic (premetrex+cisplatin regimen) or local treatment (i.e., intrapleuric)
  • ECOG Performance Status of 0, 1 or 2
  • Life expectancy of at least 3 months
  • Capability of understanding the objectives of the study and giving written informed consent
  • Willingness and ability to comply with study requirements
  • Sufficient caloric and fluid intake, including patients under enteral or parenteral nutrition

Exclusion Criteria:

  • Co-existing tumors of different histologic origin, except non melanomatous localized skin cancer and/or in situ cervical carcinoma
  • A history of earlier tumors of different histologic origin being in complete remission since less than 5 years
  • Unresolved toxicity from prior antitumor treatment(s)
  • Primary peritoneal mesothelioma
  • Any of the following abnormal baseline hematological values:

    • Hb < 9 g/dL
    • WBC < 3 x 109/L
    • Neutrophils < 1.5 x 109/L
    • Platelets < 100 x 109/L
    • Serum bilirubin > 2.5 mg/dL
    • ALAT and ASAT > 3 x UNL (unless due to liver metastases)
    • Serum creatinine > 1.5 mg/dL
  • Clinically relevant cardiovascular disease, i.e., myocardial infarction or other severe coronary artery diseases within the prior 6 months, cardiac arrythmia requiring medication, uncontrolled hypertension, overt cardiac failure or non compensated chronic heart disease in NYHA class II or more
  • History of psychiatric disabilities, potentially interfering with the capability of giving adequate informed consent
  • Pregnant or lactating women or inability/unwillingness to practice a medically approved method of contraception during study period (including 3 months following the end of treatment)
  • Uncontrolled active infections
  • Any condition which, in the judgement of the Investigator, would place the patient at undue risk or interfere with the results of the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00551252

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Contact: Camillo Porta, MD +39-0382-501355 c.porta@smatteo.pv.it

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Medical Oncology, IRCCS San Matteo University Hospital Foundation
Pavia, Italy, 27100
Principal Investigator: Camillo Porta, MD         
Sponsors and Collaborators
Gruppo Italiano MEsotelioma
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Principal Investigator: Camillo Porta, MD Medical Oncology, IRCCS San Matteo University Hospital Foundation, pavia, Italy
Additional Information:
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ClinicalTrials.gov Identifier: NCT00551252    
Other Study ID Numbers: GIMe/01/06
First Posted: October 30, 2007    Key Record Dates
Last Update Posted: October 30, 2007
Last Verified: October 2007
Additional relevant MeSH terms:
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Imatinib Mesylate
Mesothelioma, Malignant
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms, Mesothelial
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Pleural Neoplasms
Lung Diseases
Respiratory Tract Diseases
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Enzyme Inhibitors
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Protein Kinase Inhibitors