Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity
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ClinicalTrials.gov Identifier: NCT00528944 |
Recruitment Status :
Completed
First Posted : September 14, 2007
Last Update Posted : July 7, 2015
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Condition or disease |
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Emphysema |
Study Type : | Observational |
Actual Enrollment : | 73 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity |
Study Start Date : | January 2006 |
Actual Primary Completion Date : | July 2008 |
Actual Study Completion Date : | July 2008 |
Group/Cohort |
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Cohort A
Patients with obstructive defects and radiological evidence of emphysema
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Cohort B
Patients with obstructive ventilatory defects and no radiological evidence of emphysema
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Cohort C
Non-smokers without obstructive ventilatory defects or history of cardiopulmonary disease
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- Difference between DLCO SB alveolar volume and the total lung volume measurement from plethysmography [ Time Frame: 10 seconds ]To test the hypothesis that DLCO SB underestimates DLCO derived by the re-breathe DLCO maneuver, and that VA SB similarly underestimates VA RB. Alveolar volume derived with the two maneuvers will be compared with body plethysmography, the gold standard of total lung volume measurement in patients with emphysema.
- Difference between DLCO RB alveolar volume and the total lung volume measurement from plethysmography [ Time Frame: 10 seconds ]To test the hypothesis that DLCO SB underestimates DLCO derived by the re-breathe DLCO maneuver, and that VA SB similarly underestimates VA RB. Alveolar volume derived with the two maneuvers will be compared with body plethysmography, the gold standard of total lung volume measurement in patients with emphysema.

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Ages Eligible for Study: | 18 Years to 81 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- All outpatients between the ages of 18 and 81 years referred to the Columbia University Medical Center Pulmonary Diagnostic Unit between 1/18/06 and 7/30/07 for full pulmonary function evaluation, and with an obstructive ventilatory defect on spirometry, were considered eligible.
Exclusion Criteria:
- Patients who did not want to undergo the re-breathe diffusing capacity testing
- Patients who could not give informed consent;and
- Patients who were too physically compromised to undergo full testing including the re-breathe maneuver as deemed by our technicians.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00528944
United States, New York | |
Columbia University Cardiopulmonary, Sleep and Ventilatory Disorders Center | |
NY, New York, United States, 10032 |
Principal Investigator: | Robert C Basner, MD | Columbia University |
Responsible Party: | Columbia University |
ClinicalTrials.gov Identifier: | NCT00528944 History of Changes |
Other Study ID Numbers: |
AAAB6328 |
First Posted: | September 14, 2007 Key Record Dates |
Last Update Posted: | July 7, 2015 |
Last Verified: | July 2015 |
Keywords provided by Columbia University:
alveolar volume pulmonary function testing emphysema |
Additional relevant MeSH terms:
Emphysema Pulmonary Emphysema Pathologic Processes Pulmonary Disease, Chronic Obstructive |
Lung Diseases, Obstructive Lung Diseases Respiratory Tract Diseases |