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Risk Factors for Recurrent Urinary Tract Infection in Children

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ClinicalTrials.gov Identifier: NCT00528476
Recruitment Status : Completed
First Posted : September 12, 2007
Last Update Posted : September 12, 2007
Sponsor:
Information provided by:
Kaunas University of Medicine

Brief Summary:
The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.

Condition or disease
Urinary Tract Infection Pyelonephritis Cystitis

Detailed Description:

It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.


Study Type : Observational
Actual Enrollment : 161 participants
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children
Study Start Date : November 2004
Actual Study Completion Date : January 2007

Resource links provided by the National Library of Medicine


Group/Cohort
Case: 1
Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.
Control: 2
Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).




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Ages Eligible for Study:   5 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion Criteria:

  • urinary tract malformations
  • neurogenic bladder dysfunction
  • patients, who received immunosuppressive drugs
  • pregnant girls
  • children with non bacterial urinary tract infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00528476


Locations
Lithuania
Kaunas University of Medicine
Kaunas, Lithuania, 44307
Sponsors and Collaborators
Kaunas University of Medicine
Investigators
Principal Investigator: Sarunas Rudaitis, MD Clinic of Children's Diseases, Kaunas University of Medicine
Study Chair: Birute Pundziene, MD, PhD Clinic of Children's Diseases, Kaunas University of Medicine

ClinicalTrials.gov Identifier: NCT00528476     History of Changes
Other Study ID Numbers: BE-2-68
First Posted: September 12, 2007    Key Record Dates
Last Update Posted: September 12, 2007
Last Verified: September 2007

Keywords provided by Kaunas University of Medicine:
pyelonephritis
cystitis
risk factor
children
urodynamics

Additional relevant MeSH terms:
Infection
Communicable Diseases
Urinary Tract Infections
Cystitis
Pyelonephritis
Urologic Diseases
Urinary Bladder Diseases
Nephritis, Interstitial
Nephritis
Kidney Diseases
Pyelitis