Working… Menu

Is There Increased Polyethylene Wear and Increased Periprosthetic Bone Loss in Femur in Reverse Hybrid Technique Compared With Conventional Cemented Technique in Total Hip Replacement?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00526539
Recruitment Status : Completed
First Posted : September 10, 2007
Last Update Posted : July 6, 2011
Information provided by:
Oslo University Hospital

Brief Summary:

Total hip replacement is a very cost effective procedure to enhance life quality in a group of patients. In the period 2000-2004 7-8000 procedures were preformed, 13% were revisions (1). Historically, many different principles have been used from the first resurfacings to cemented and uncemented total hip replacements as we know them today. In 2000, 28 different femoral stems and 26 different acetabular components were in regular use in Norway. There are several well-documented cemented acetabular components, but no such uncemented cup. On the femoral side there are several well-documented stems both cemented and uncemented. (2).

From the late 1990`s a reverse hybrid (uncemented stem and cemented cup) is being more frequently used. In 2004 a total of 276 reverse hybrid hips were done and the trend is increasing. (1). This technique is solely based on experience and the fact that one combines the better of two principles (cemented and uncemented). There is no scientific evidence that this technique is as good or better than a cemented THR.

One of the potential problems with hydroxyapatite coated components is that it is suspected that it may increase wear due to the particle theory. (3,4). There are no prospective randomised controlled RSA and DXA studies that conclude on this matter. This is such a study and our hypothesis is that there is no difference in wear or osteolysis between the methods.

Condition or disease Intervention/treatment Phase
Osteoarthritis Other: Total hip replacement, Spectron and Taperloc Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hip Replacement

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   up to 75 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Osteoarthritis
  • Indication for THR

Exclusion Criteria:

  • Significant anatomical abnormalities
  • Rheumatoid artheritis, dysplasia, fracture sequela

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00526539

Sponsors and Collaborators
Ullevaal University Hospital
Layout table for investigator information
Study Chair: Lars Nordsletten, professor, MD, Ph.D Ullevål University Hospital, N-0407 Oslo
Principal Investigator: Einar Lindalen, MD Lovisenberg Hospital, N- 0440 Oslo

Layout table for additonal information Identifier: NCT00526539     History of Changes
Other Study ID Numbers: Reverse hybrid vs cemented THR
First Posted: September 10, 2007    Key Record Dates
Last Update Posted: July 6, 2011
Last Verified: September 2007
Keywords provided by Oslo University Hospital:
reversed hybrid
Additional relevant MeSH terms:
Layout table for MeSH terms
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases