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Complex Problem Solving Training in Schizophrenic Patients

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ClinicalTrials.gov Identifier: NCT00507988
Recruitment Status : Completed
First Posted : July 27, 2007
Last Update Posted : May 15, 2009
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
Heidelberg University

Study Description
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Brief Summary:
The primary purpose of the study is to assess whether a planning and problem-solving training is more effective in improving work therapy performance in patients with schizophrenia than traditional training programs addressing basic cognitive functions.

Condition or disease Intervention/treatment Phase
Schizophrenia Schizoaffective Disorder Behavioral: Complex Problem Solving Training Behavioral: Basic Cognitive Training Not Applicable

Detailed Description:
In patients with schizophrenia, cognitive deficits often lead to an impairment in daily life. This observation has led to the development of cognitive training packages aiming a improving these deficits. However, it is far from clear which level of cognitive functioning provides the best target for cognitive interventions. Traditionally, training has aimed a basic cognitive functions like attention and memory. In the present study we aim at a higher-level of function, namely planning and problem-solving skills, which are trained using the software package Plan-A-Day. The primary hypothesis is that complex problem solving training improved functional capacity more than traditional training programs addressing basic cognitive function.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 91 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Complex Problem Solving Training in Schizophrenic Patients
Study Start Date : August 2007
Actual Primary Completion Date : February 2009
Actual Study Completion Date : February 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Arms and Interventions
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Arm Intervention/treatment
Experimental: A
Complex Problem Solving Training
 Behavioral: Complex Problem Solving Training
10 sessions of 45 minutes complex problem solving training over 3 weeks (including 30 minutes of computerized planning and problem-solving training with Plan-A-Day and 15 minutes group session for transfer to everyday situations)
Active Comparator: B
Basic Cognitive Training
 Behavioral: Basic Cognitive Training
10 sessions over 3 weeks of 45 min basic cognitive training (including 45 min computerized training of attention, processing speed, memory)


Outcome Measures
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Primary Outcome Measures :
  1. Functional Capacity as assessed by Osnabrücker Arbeitsfähigkeitsprofil "learning ability" subscale [ Time Frame: 3 weeks ]

Secondary Outcome Measures :
  1. Functional Capacity as assessed by the Osnabrücker-Arbeitsfähigkeitsprofil summary score [ Time Frame: 3 weeks ]
  2. BADS Zoo Map Score (Neuropsychological Test) [ Time Frame: 3 weeks ]
  3. Planungstest (Tower of London) Summary Score (Neuropsychological Test) [ Time Frame: 3 weeks ]
  4. Plan-A-Day S Solution Time (Neuropsychological Test) [ Time Frame: 3 weeks ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with schizophrenic or schizoaffective Disorder (DSM IV)
  • Remitted positive symptoms (PANSS positive all ≤ 4), clinical stability
  • Native German speaker
  • Verbal IQ > 80
  • Visual acuity normal or corrected to normal

Exclusion Criteria:

  • Concurrent Axis-I disorder
  • Drug abuse during last 2 months
  • Neurological or medical conditions potentially affecting cognition
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00507988


Locations
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Germany
SRH Klinikum Karlsbad-Langensteinbach
Karlsbad, Germany, 76307
Sponsors and Collaborators
Heidelberg University
German Federal Ministry of Education and Research
Investigators
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Principal Investigator: Matthias Weisbrod, MD SRH Klinikum Karlsbad-Langensteinbach, Department of Psychiatry
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Irmtraut Gürkan, University Hospital Heidelberg
ClinicalTrials.gov Identifier: NCT00507988    
Other Study ID Numbers: 01GW0630
First Posted: July 27, 2007    Key Record Dates
Last Update Posted: May 15, 2009
Last Verified: May 2009
Keywords provided by Heidelberg University:
Cognitive Training
Complex Problem Solving
Goal Management
Planning
Additional relevant MeSH terms:
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Schizophrenia
Psychotic Disorders
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders