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Anisometropia Amblyopia Improved by Perceptual Learning and Patching

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00498641
Recruitment Status : Completed
First Posted : July 10, 2007
Last Update Posted : July 10, 2007
Information provided by:
Tri-Service General Hospital

Brief Summary:
To compare the effects of perceptual learning with patching on improving visual acuity and contrast sensitivity in payient with anisometropic amblyopia.

Condition or disease Intervention/treatment Phase
Anisometropic Amblypia Procedure: computer program and patching Phase 3

Detailed Description:
Patients with anisometropic amblyopia were randomized to patching or perceptual learning group. Corrected amblyopic logMAR visual acuity and contrast sensitivity function were measured at four-weekly intervals until visual acuity stabilized or amblyopia resolved. Improvement in visual acuity, contrast sensitivity, and the resolution of amblyopia were compared between groups.

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Study Start Date : January 2005
Actual Study Completion Date : January 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Amblyopia

Primary Outcome Measures :
  1. Corrected amblyopic logMAR visual acuity and contrast sensitivity function

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 55 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Anisometropia without strabismus
  • An interocular acuity difference of at least 0.2 logMAR in children (3-7 years of age) or in older children and adult patients without a history of patching or atropine penalization
  • All patients wore their spectacle at least one year

Exclusion Criteria:

  • A history of prior spectacle correction
  • A history of patching or optical penalization
  • The existence of an ocular disease that could contribute to decreased visual acuity
  • Learning difficulties
  • The presence of strabismus

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00498641

Sponsors and Collaborators
Tri-Service General Hospital
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Study Director: Po Chen, MD Tri-Service General Hospital
Layout table for additonal information Identifier: NCT00498641    
Other Study ID Numbers: 094-05-0112
First Posted: July 10, 2007    Key Record Dates
Last Update Posted: July 10, 2007
Last Verified: July 2007
Keywords provided by Tri-Service General Hospital:
perceptual learning
occlusion therapy