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Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

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ClinicalTrials.gov Identifier: NCT00454415
Recruitment Status : Completed
First Posted : March 30, 2007
Last Update Posted : December 27, 2012
Information provided by (Responsible Party):

Study Description
Brief Summary:
Asthma is a common illness among children in the United States. While there are many known causes of asthma, including tobacco smoke, pollen, dust, or other allergens, the exact cause of asthma in some individuals remains unknown. This study will examine the role that specific dietary factors and body mass index (BMI) play in the development of childhood asthma.

Condition or disease

Detailed Description:

Asthma prevalence has steadily increased in the United States since the early 1980s, but the exact cause of this increase remains unknown. It is estimated that at least 8% of Americans have asthma. Although anti-inflammatory medications have proven effective for decreasing asthma exacerbations, there are few treatment options available to prevent the initial onset of the disease. Dietary factors and BMI may play a role in the development of asthma. Specifically, individuals who eat foods containing antioxidants (e.g., vitamin C, vitamin E, and carotenoids), n-3 polyunsaturated fatty acids (e.g., fish oils), and vitamin D may have a decreased risk of developing asthma, while individuals with higher BMI ratios may have an increased asthma risk. The purpose of this study is to evaluate the relationship among dietary factors, BMI, and the incidence of asthma among children.

This study will enroll children participating in the Growing Up Today study and children of nurses who are participating in the Nurses Health Study II. Researchers will analyze participants' previously completed questionnaires on dietary intake, physical activity, height, weight, and the presence of physician-diagnosed asthma. All participants with physician-diagnosed asthma will receive an additional asthma questionnaire. A small portion of these participants will also have their medical records reviewed by study researchers, and mothers of these children will be asked to complete a questionnaire. Additionally, a questionnaire will be sent to and completed by children who do not have asthma and their mothers.

Study Design

Study Type : Observational
Actual Enrollment : 16000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
Study Start Date : January 2007
Primary Completion Date : December 2008
Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Primary Outcome Measures :
  1. incident asthma [ Time Frame: childhood ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   9 Years to 14 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
U.S. children

Inclusion Criteria:

  • Children of women in the Nurses Health Study II (NHS2)
  • Participated in the Growing Up Today study

Exclusion Criteria:

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00454415

United States, Massachusetts
Channing Laboratory, Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Brigham and Women's Hospital
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Carlos A. Camargo, MD, DrPH Channing Laboratory, Brigham and Women's Hospital
More Information

Responsible Party: Carlos A. Camargo, Professor of Medicine, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT00454415     History of Changes
Other Study ID Numbers: 1376
R01HL084401-01A1 ( U.S. NIH Grant/Contract )
First Posted: March 30, 2007    Key Record Dates
Last Update Posted: December 27, 2012
Last Verified: December 2012

Keywords provided by Carlos A. Camargo, Brigham and Women's Hospital:
Body Mass Index

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases