Working… Menu

The Genetic and Life Style Determinants of Bone Mass of Young Greek Males

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00449215
Recruitment Status : Completed
First Posted : March 20, 2007
Last Update Posted : March 20, 2007
Information provided by:
University of Athens

Brief Summary:

The genetic bases of peak bone mass in males, as determinants of an individual’s risk of developing osteoporotic fractures in old age and their interaction with dietary and lifestyle factors are still poorly understood.

Our objective was to examine the relative contribution of genetic and environmental variables to the regulation of peak bone mass in a population-based cohort of young healthy men, focusing on the BsmI polymorphism of vitamin D receptor (VDR)gene and the AluI polymorphism of calcitonin receptor (CTR)gene.

Condition or disease

  Show Detailed Description

Layout table for study information
Study Type : Observational
Enrollment : 301 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Study Start Date : October 2004
Actual Study Completion Date : December 2006

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   16 Years to 35 Years   (Child, Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Greek healthy young men

Exclusion Criteria:

  • Men who were treated with corticosteroids, anticonvulsants, or anticoagulants or who suffered from hypogonadism, kidney, liver, thyroid and gastrointestinal disease or diabetes mellitus were excluded from the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00449215

Layout table for location information
Laboratory for Research of Musculoskeletal System, University of Athens
Athens, Greece, 14561
Sponsors and Collaborators
University of Athens
Layout table for investigator information
Principal Investigator: Ioannis N Charopoulos, M.D Laboratory Of Research Of Musculoskeletal System

Additional Information:
Layout table for additonal information Identifier: NCT00449215     History of Changes
Other Study ID Numbers: AA-88-H-0010
First Posted: March 20, 2007    Key Record Dates
Last Update Posted: March 20, 2007
Last Verified: March 2007
Keywords provided by University of Athens:
Peak Bone Mass; Male; Genetic Polymorphisms
Additional relevant MeSH terms:
Layout table for MeSH terms
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases