COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu
Trial record 1 of 1 for:    NCT00446212
Previous Study | Return to List | Next Study

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00446212
Recruitment Status : Completed
First Posted : March 12, 2007
Last Update Posted : May 30, 2013
Information provided by (Responsible Party):
Melbourne Health

Brief Summary:
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Condition or disease Intervention/treatment Phase
Anaesthesia Drug: Propofol Drug: desflurane Phase 4

Detailed Description:
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 300 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Study Start Date : August 2006
Actual Primary Completion Date : July 2008
Actual Study Completion Date : July 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: 1
Propofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics
Drug: Propofol
target controlled infusion of propofol

Active Comparator: 2
Desflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics
Drug: desflurane
Anaesthetic maintenance with desflurane

Primary Outcome Measures :
  1. Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire [ Time Frame: recovery room stay ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male and female patients
  • Age between 18 and 50 years
  • Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

  • Inadequate English language comprehension
  • Major drug abuse problem

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00446212

Layout table for location information
Australia, Victoria
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Australia, Western Australia
Royal Perth Hospital
Perth, Western Australia, Australia, 6000
King Edward Memorial Hospital for Women
Subiaco, Western Australia, Australia, 6008
New Zealand
Waikato Hospital
Hamilton, New Zealand
Sponsors and Collaborators
Melbourne Health
Layout table for investigator information
Principal Investigator: Kate Leslie, MD Melbourne Health
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Melbourne Health Identifier: NCT00446212    
Other Study ID Numbers: 2006.125
First Posted: March 12, 2007    Key Record Dates
Last Update Posted: May 30, 2013
Last Verified: May 2013
Keywords provided by Melbourne Health:
Additional relevant MeSH terms:
Layout table for MeSH terms
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Inhalation