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Trial record 44 of 231 for:    CALCITONIN SALMON

Drug Interaction of SMC021 With Concomitant Antacid (Calcium Carbonate/Magnesium Hydroxide).

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00421590
Recruitment Status : Completed
First Posted : January 12, 2007
Last Update Posted : June 22, 2007
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Brief Summary:
This study will assess the effect of concomitant antacid on the pharmacokinetics and pharmacodynamics of SMC021

Condition or disease Intervention/treatment Phase
Health Postmenopausal Women Drug: SMC021 Phase 2

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Study Type : Interventional  (Clinical Trial)
Enrollment : 38 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: A Randomized, Partially Blind, Placebo Controlled, Crossover, Single Oral Dose Study to Assess the Effect of Concomitant Antacid (Calcium Carbonate / Magnesium Hydroxide) on the Pharmacokinetics and Pharmacodynamics of SMC021 (0.8 mg Salmon Calcitonin/200 mg 5-CNAC) in Healthy Postmenopausal Women
Study Start Date : October 2006

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MedlinePlus related topics: Calcium

Primary Outcome Measures :
  1. To assess the effect of concomitant antacid (calcium carbonate / magnesium hydroxide) on the pharmacokinetics and pharmacodynamics (decrease in serum CTX-I) of SMC021 (0.8 mg salmon calcitonin/200 mg 5-CNAC)

Secondary Outcome Measures :
  1. To assess the tolerability of concomitantly-administered antacid and SMC021

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy postmenopausal female subjects, 40 to 70 years of age, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening.
  • At Screening, and Baseline, vital signs (systolic and diastolic blood pressure and pulse rate) will be assessed after the subject has rested for at least three (3) minutes. All blood pressure measurements at other time-points should be assessed with the subject seated, and utilizing the same arm for each determination.
  • Postmenopausal women must have no regular menstrual bleeding for at least 5 years prior to inclusion or must have been surgically sterilized at least 6 months prior to screening.
  • Body mass index (BMI) must be within the range of 18 to 30. Subjects must weigh at least 50 kg to participate in this study.
  • Able to communicate well with the investigator, to understand and comply with the requirements of the study. Understand and sign the written informed consent.

Exclusion Criteria:

  • Smokers who report cigarette use of ≥ 5 cigarette per day. Smoking will not be allowed on the days of each dosing up to the last blood sampling or the last assessment.
  • Use of any prescription drugs or over-the-counter (OTC) medication (vitamins, herbal supplements, dietary supplements) started within the last month prior to screening.
  • Participation in any clinical investigation within 4 weeks prior to dosing, or less than 10 times the corresponding half life of the drug taken.
  • The current or previous treatment that would affect bone metabolism/remodeling.
  • Donation or loss of 400 mL or more of blood within 8 weeks prior to first dosing, or longer if required by local regulation.
  • Subjects with a hemoglobin level equal to or below 7.5 mmol/L at screening.
  • Significant illness within two weeks prior to dosing.
  • A past medical history of clinically significant ECG abnormalities or a family history grandparents, parents and siblings) of a prolonged QT-interval syndrome.
  • History of autonomic dysfunction (e.g. history of fainting, orthostatic hypotension, sinus arrhythmia).
  • History of acute or chronic bronchospastic disease (including asthma and chronic obstructive pulmonary disease, treated or not treated),
  • History of clinically significant drug allergy or history of atopic allergy (asthma, urticaria, eczematous dermatitis). A known hypersensitivity to the study drug or drugs similar to the study drug.
  • Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of drugs or which may jeopardize the subject in case of participation in the study.
  • Poorly controlled diabetes
  • History of malignancy of any organ system within the past 5 years
  • A positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result.
  • HIV positive
  • History of drug or alcohol abuse within the 12 months prior to dosing.

Other protocol-defined inclusion/exclusion criteria may apply

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00421590

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Novartis Investigative site
Copenhagen, Denmark
Sponsors and Collaborators
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Principal Investigator: Novartis Investigative site

Layout table for additonal information Identifier: NCT00421590     History of Changes
Other Study ID Numbers: CSMC021C2208
First Posted: January 12, 2007    Key Record Dates
Last Update Posted: June 22, 2007
Last Verified: June 2007
Keywords provided by Novartis:
Randomized, partially blind, placebo controlled, crossover, drug interaction with concomitant antacid, pharmacokinetics, pharmacodynamics, SMC021
Additional relevant MeSH terms:
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Calcium Carbonate
Magnesium Hydroxide
Anti-Ulcer Agents
Calcium-Regulating Hormones and Agents
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Gastrointestinal Agents