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Non Alcoholic Fatty Liver Disease in Rheumatoid Arthritis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00394238
Recruitment Status : Unknown
Verified July 2006 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : October 31, 2006
Last Update Posted : October 31, 2006
Information provided by:
Shaare Zedek Medical Center

Brief Summary:

Rheumatoid arthritis is a chronic inflammatory systemic disease. It has a worldwide distribution and can affect all age group. The peak incidence is between fourth and sixth decade. It is more prevalent in women, and it's prevalence in the general population in North America is between 0.2-1.5%. The etiology of RA is unknown, although clusters of the disease in families and high concordance in mono-zydotic twins support genetic predisposition. The prevalence of fatty liver disease in patients with rheumatoid arthritis is currently unknown. We wish to study the link between the two conditions by performing a son graphic imaging of the liver in a cohort of RA patients. If indeed a high prevalence of NAFLD will be found in the RA patients, further support will be landed for the link between inflammation and fatty liver disease. These findings may also have implications regarding the management and follow up of RA patients.

The validity of sonographic imaging for detection of fatty liver diseases is currently accepted: On ultrasonographic, fatty infiltration of the liver produces a diffuse increase in echogenicity as compared with that of the kidneys. Ultrasonography has a sensitivity of 89% and a specificity of 93% in detecting steatosis and sensitivity and specificity of 77% and 89% respectively in detecting increase fibrosis.

In view of all the above data, we expected to find higher prevalence of fatty liver in the patients with higher inflammation markers compare with patients with lower markers.

Condition or disease Intervention/treatment
Arthritis, Rheumatoid Procedure: Ultrasonographic imaging

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Study Type : Observational
Enrollment : 50 participants
Observational Model: Defined Population
Time Perspective: Other
Study Start Date : November 2006
Study Completion Date : October 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Rheumatoid arthritis

Exclusion Criteria:

  • Age below 18

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00394238

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Contact: Ornit Cohen, Msc 0507867234

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Rheumatoid Clinic
Jerusalem, Israel
Contact: Michal Mates, MD    0544727635   
Contact: Ornit Cohen, MSc    0507867234   
Principal Investigator: Michal Mates, MD         
Sponsors and Collaborators
Shaare Zedek Medical Center
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Principal Investigator: Michal Mates, MD Shaare Zedek Medical Center Jerusalem
Layout table for additonal information Identifier: NCT00394238    
Other Study ID Numbers: 20174CTIL
First Posted: October 31, 2006    Key Record Dates
Last Update Posted: October 31, 2006
Last Verified: July 2006
Additional relevant MeSH terms:
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Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases