Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
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ClinicalTrials.gov Identifier: NCT00392275
Recruitment Status :
First Posted : October 25, 2006
Last Update Posted : April 10, 2013
Indiana University School of Medicine
Information provided by (Responsible Party):
Indiana University ( Indiana University School of Medicine )
Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
All patients with functioning filtering blebs will be evaluated prospectively for inclusion
Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following exclusion criteria:
Ongoing ocular inflammatory disease
Bleb leakage - determined by Seidel test
Known contraindications to use of any of these study medications.