Strength Training Effectiveness Post-Stroke (STEPS)
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|ClinicalTrials.gov Identifier: NCT00389012|
Recruitment Status : Completed
First Posted : October 17, 2006
Last Update Posted : April 6, 2017
|Condition or disease||Intervention/treatment||Phase|
|Cerebrovascular Accident||Procedure: exercise therapy Procedure: walking rehabilitation||Phase 2|
Impaired walking ability is a hallmark residual deficit that contributes to post-stroke walking disability . Impairment in lower extremity muscle strength is a significant contributor to decreased walking speed after stroke. No studies have combined task-specific locomotor training in combination with lower extremity strength training programs designed to improve post-stroke walking outcomes.
Participants will include individuals who are ambulatory, but walk slower than 1.0 m/sec and are at least 6 months post unilateral stroke.
Participants are stratified by initial comfortable walking speed (moderate >0.5 m/sec; severe <= 0.5 m/sec) and randomized to one of four exercise pairs: 1) body-weight supported treadmill training (BWST) and locomotor-based strength training (resistive cycling task, LBST), 2) BWST and LE muscle-specific strength training (MSST), 3) BWST and upper extremity ergometry (SHAM), and 4) LBST and SHAM. Training will occur 4 times per week for 6 weeks (24 total sessions). Exercise type in each exercise pair is alternated daily.
Primary outcomes include comfortable and fast overground walking speed, and distance walked in 6-minutes measured at baseline, after 12 and 24 treatment sessions and at a 6-month follow-up.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||80 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Strength Training Effectiveness Post-Stroke (STEPS)|
|Study Start Date :||May 2004|
|Actual Primary Completion Date :||October 31, 2010|
|Actual Study Completion Date :||October 31, 2010|
- walking speed (meters/second)
- walking distance (distance walked in 6-minutes)
- Lower extremity Fugl-Meyer
- Berg Balance Score
- Lower extremity torque
- Stroke Impact Scale
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00389012
|United States, California|
|Rancho Los Amigos|
|Downey, California, United States, 90242|
|University of Southern California|
|Los Angeles, California, United States, 90089|
|United States, Illinois|
|Chicago, Illinois, United States, 60611|
|Principal Investigator:||Katherine J Sullivan, PhD, PT||Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California|
|Principal Investigator:||David A Brown, PhD, PT||Department of Physical Therapy and Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois|
|Principal Investigator:||Sara Mulroy, PhD, PT||Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California|