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Addressing Vertebral Osteoporosis Incidentally Detected to Prevent Future Fractures (AVOID Fracture)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00388908
Recruitment Status : Completed
First Posted : October 17, 2006
Last Update Posted : July 28, 2015
Canadian Institutes of Health Research (CIHR)
Information provided by:
University of Alberta

Brief Summary:
Osteoporosis is a common and progressive condition that leads to broken bones (fractures), which cause pain, disability, deformity, and even death. There are new treatments available that can decrease the risk of a fracture by 50%, and the people who benefit the most are those with osteoporosis who have already had a fracture, like a vertebral (spine) fracture. Vertebral fractures are usually "silent," and ~20% of people over the age of 60 years have had one although they don't know it. Many of these people have had chest x-rays done for other reasons, and these x-rays can incidentally detect these silent fractures. Although most people with a vertebral fracture should be tested and treated for osteoporosis, studies demonstrate that less than one-quarter of older people with a vertebral fracture are ever investigated or even treated. This reflects a gap between evidence-based best practice and everyday practice in the community. The proposed research addresses this care-gap by using a quality improvement intervention that uses chest x-rays done in the Emergency Department to remind family physicians about osteoporosis while providing them with evidence-based treatment guidelines - with or without educating and empowering patients about osteoporosis. The effectiveness of this intervention will be compared to usual care in a controlled trial. The intent of this research is to improve quality of care for patients at high risk of fracture, by increasing rates of testing and treatment of osteoporosis.

Condition or disease Intervention/treatment Phase
Osteoporosis Behavioral: Reminders and opinion leader generated guidelines +/- leaflets and counselling Other: Usual Care Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 240 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Addressing Vertebral Osteoporosis Incidentally Detected to Prevent Future Fractures: The AVOID FRACTURE Study
Study Start Date : November 2006
Actual Primary Completion Date : December 2010
Actual Study Completion Date : July 2012

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: A
Multifaceted intervention
Behavioral: Reminders and opinion leader generated guidelines +/- leaflets and counselling
Active Comparator: B
Usual Care
Other: Usual Care

Primary Outcome Measures :
  1. The primary outcome is the proportion of patients starting prescription osteoporosis treatment within 3 months of fracture recognition [ Time Frame: 3 months ]

Secondary Outcome Measures :
  1. Secondary outcomes include BMD testing, diagnosis of osteoporosis, knowledge, and quality of life. [ Time Frame: 3 months ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age 60 years or greater
  • chest radiograph that reports the presence of a vertebral fracture
  • discharged home.

Exclusion Criteria:

  • unable to provide simple informed consent or unwilling to participate in the study
  • unable to read, understand, and converse in English
  • admitted to hospital
  • currently enrolled in the pilot study or other osteoporosis-related studies
  • currently taking any prescription osteoporosis treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00388908

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Canada, Alberta
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Sponsors and Collaborators
University of Alberta
Canadian Institutes of Health Research (CIHR)
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Principal Investigator: Sumit R. Majumdar, MD, MPH University of Alberta
Publications of Results:
Other Publications:
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Responsible Party: Sumit R. Majumdar, University of Alberta Identifier: NCT00388908    
Other Study ID Numbers: CIHR-MOP-79325
First Posted: October 17, 2006    Key Record Dates
Last Update Posted: July 28, 2015
Last Verified: July 2015
Keywords provided by University of Alberta:
vertebral fractures
quality improvement
Additional relevant MeSH terms:
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Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases