Role of B2 Adrenergic Receptors in Labor Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00385294
Recruitment Status : Completed
First Posted : October 9, 2006
Last Update Posted : July 18, 2018
Information provided by (Responsible Party):
Pamela Flood, Columbia University

Brief Summary:
The study aims to understand why labor is more painful for some women compared to others. The study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

Condition or disease
Pain Pain Threshold Labour Pain

Detailed Description:
Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. The study will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. The investigators will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

Study Type : Observational
Actual Enrollment : 150 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Role of B2 Adrenergic Receptors in Labor Pain
Study Start Date : September 2006
Actual Primary Completion Date : January 2009
Actual Study Completion Date : January 2009

Biospecimen Retention:   Samples With DNA
DNA identified by subject number will be retained for analysis.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Nuliparous women anticipating NSVD

Inclusion Criteria:

  • nulliparous women
  • Third trimester of pregnancy on enrollment

Exclusion Criteria:

  • Chronic Pain
  • Pain medication utilization
  • Large for gestational age baby
  • Small for gestational age baby
  • Systemic illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00385294

United States, New York
Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
Columbia University
Principal Investigator: Pamela D. Flood, M.D. Columbia University

Responsible Party: Pamela Flood, Professor of Anesthesiology, Columbia University Identifier: NCT00385294     History of Changes
Other Study ID Numbers: AAAB3535
First Posted: October 9, 2006    Key Record Dates
Last Update Posted: July 18, 2018
Last Verified: July 2018

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Pamela Flood, Columbia University:

Additional relevant MeSH terms:
Labor Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs