To Compare the Ischemic Pre-conditioning and Post-conditioning on Reperfusion Injury in Humans.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00385151
Recruitment Status : Completed
First Posted : October 6, 2006
Last Update Posted : November 18, 2013
Information provided by (Responsible Party):
Arshed A. Quyyumi, Emory University

Brief Summary:

Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis. A phenomenon known as Pre-conditioning has been identified to limit the the extent and severity of reperfusion injury but it is very difficult to apply it in patient care setting as timing of acute cardiac or neurologic ischemic event is difficult to reliably predict.

Postconditioning or ischemic postconditioning is well known to attenuate the reperfusion injury. There is enough data that shows the benefit of post conditioning in reducing the reperfusion injury in animals. However postconditioning in humans has not been investigated.

We hypothesize that Post conditioning will attenuate the reperfusion injury and will be comparable to the effect of preconditioning in humans.

Condition or disease
Endothelial Dysfunction

  Show Detailed Description

Study Type : Observational
Enrollment : 20 participants
Time Perspective: Prospective
Official Title: The Mechanism of Ischemic Post Conditioning in Humans, Minimizing Reperfusion Injury.
Study Start Date : May 2006
Study Completion Date : August 2006

Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 35 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male and female volunteers between the ages of 18 and 35.
  • Able to give informed and witnessed consent.
  • Don't have the following risk factor

    1. Non smoker
    2. LDL<180, HDL>30, TG<200 or LDL/HDL<6.0
    3. Does not have diabetes mellitus .
    4. BP < 135/85
    5. Do not have family history defined as a parent or sibling with coronary disease diagnosed before age 40. .

Exclusion Criteria:

  • Patients with significant medial illness for which they are receiving continued monitoring or treatment, known cardiovascular disease, or risk factors for coronary artery disease are excluded. These risk factors include

    1. Smoking
    2. Hyperlipidemia defined as and LDL>180, HDL<30, TG>200 or LDL/HDL>6.0
    3. Diabetes mellitus
    4. Hypertension,
    5. Strong family history defined as a parent or sibling with coronary disease diagnosed before age 40.

The exclusion criteria are to prevent the confounding effects of atherosclerosis or other medical conditions in our study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00385151

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
Principal Investigator: Tarek Helmy, MD Emory University
Principal Investigator: Arshed Ali Quyyumi, MD Emory University
Study Director: Muhammad Amer, MD Emory University

Responsible Party: Arshed A. Quyyumi, Principal Investigator, Emory University Identifier: NCT00385151     History of Changes
Other Study ID Numbers: 0920-2004
First Posted: October 6, 2006    Key Record Dates
Last Update Posted: November 18, 2013
Last Verified: November 2013

Keywords provided by Arshed A. Quyyumi, Emory University:
Post conditioning

Additional relevant MeSH terms:
Reperfusion Injury
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications
Pathologic Processes