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Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups

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ClinicalTrials.gov Identifier: NCT00377702
Recruitment Status : Completed
First Posted : September 18, 2006
Last Update Posted : February 18, 2016
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Study Description
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Brief Summary:
Cardiovascular disease (CVD) is one of the leading causes of death in the United States. Currently, there is little information about the lifetime risk of CVD among non-white ethnic groups. This study will analyze data from participants in several ongoing clinical studies to identify the lifetime risk for CVD among various ethnicities.

Condition or disease
Cardiovascular Diseases Coronary Disease Heart Failure, Congestive Atrial Fibrillation

Detailed Description:

CVD affects millions of people in the United States. Current treatment guidelines for CVD take into account an individual's risk of developing the disease within 10 years; the intensity of therapy is usually matched to the 10-year risk magnitude. However, many individuals have a low 10-year risk of CVD, but have an elevated lifetime risk of developing the disease. Unfortunately, few studies have examined the lifetime risks for CVD, and these studies have been almost exclusively performed in the Caucasian population. There have been no studies that focus on the lifetime risks for CVD among other ethnic groups. Because the incidence of CVD and other causes of death vary among different ethnic groups, it is important to examine each group separately. Using data from ongoing clinical studies, this study will evaluate the lifetime risks for CVD among different ethnic groups. The results from this study will assist in estimating the future incidence of CVD among ethnic groups, improving risk communication within patient care, and identifying new populations of individuals at risk for CVD.

This study will use previously collected data on 500,000 individuals participating in pre-specified clinical studies. Some of the participating studies include the following: Atherosclerosis Risk in Communities, Framingham Heart, Honolulu Heart, Puerto Rico Heart Health, Coronary Artery Risk Development in Young Adults (CARDIA), Cardiovascular Health, Chicago Heart Association Detection Project in Industry, Women's Health Initiative Observational Studies, and Multiple Risk Factor Intervention Trial (MRFIT). There will be no study visits specifically for this study. Researchers will collect information on CVD risk factors and demographics, including sex, race, and age; they will then compare this information to overall survival, CVD associated survival, and lifetime risk for CVD.

Study Design
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Study Type : Observational
Enrollment : 500000 participants
Time Perspective: Retrospective
Official Title: Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular Disease
Study Start Date : July 2006
Actual Study Completion Date : July 2006

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Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Participating in a specified epidemiologic study

Exclusion Criteria:

  • Pre-existing CVD prior to study entry
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00377702


Locations
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United States, Illinois
Northwestern University Department of Preventive Medicine
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
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Principal Investigator: Donald M. Lloyd-Jones, MD, ScM Northwestern University
More Information
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ClinicalTrials.gov Identifier: NCT00377702    
Other Study ID Numbers: 1350
R21HL085375 ( U.S. NIH Grant/Contract )
First Posted: September 18, 2006    Key Record Dates
Last Update Posted: February 18, 2016
Last Verified: December 2007
Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
Coronary Heart Disease
Risk Factors
Heart Failure
Additional relevant MeSH terms:
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Heart Failure
Atrial Fibrillation
Cardiovascular Diseases
Coronary Disease
Heart Diseases
 Arrhythmias, Cardiac
Pathologic Processes
Myocardial Ischemia
Vascular Diseases