Collection of Blood Samples From SMART Study Participants for Future Genetic Studies
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00377169|
Recruitment Status : Completed
First Posted : September 15, 2006
Last Update Posted : November 1, 2016
|Condition or disease|
Despite progress in the treatment of HIV and a greater understanding of the pathophysiology of HIV infection, there are still unexplained differences in both the progression of untreated HIV infection and response to antiretroviral therapy. These differences are likely related to the unique genetic makeup of individuals with HIV infection. Particular genes may offer protection against HIV infection, while other genes may make disease progression more likely. Knowing more about the genetic makeup of HIV infected individuals may lead to the development of a targeted treatment strategy based on an individual's specific risk of disease progression and sensitivity to medication toxicity. The purpose of this substudy is to collect blood samples from SMART study participants. The samples will be used in future Community Programs for Clinical Research on AIDS (CPCRA) studies investigating the link between human genetic factors and clinical outcome data.
This study will enroll individuals currently participating in the SMART study. Participants will provide one blood sample. Individual test results from future blood analyses will not be provided to a patient unless they may have profound health implications for that patient.
|Study Type :||Observational|
|Estimated Enrollment :||3261 participants|
|Official Title:||Genomics: A Substudy of a Large, Simple Trial Comparing Two Strategies for Management of Anti-Retroviral Therapy (The SMART Study)|
|Actual Primary Completion Date :||January 2006|
|Actual Study Completion Date :||January 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00377169
|Study Chair:||Jonathan Uy, MD||AIDS Research Alliance Chicago (ARAC), University of Illinois at Chicago|
|Study Chair:||Roberto Arduino, MD||The University of Texas Health Science Center, Houston|
|Study Chair:||Fraser Drummond, MBChB, MRCA, DA (UK)||National Centre in HIV Epidemiology and Clinical Research, University of New South Wales|
|Study Chair:||Daniela Gey, MD||Copenhagen HIV Programme, Hvidovre University Hospital|
|Study Chair:||Adrian Palfreeman, MD||Peterborough and Stamford Hospitals NHS Foundation Trust|