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The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00374894
Recruitment Status : Completed
First Posted : September 12, 2006
Last Update Posted : September 12, 2006
Information provided by:
China Medical University, China

Brief Summary:
Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition or disease Intervention/treatment
Lead Poisoning Drug: 2,3-dimercaptosuccinic acid

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Study Type : Observational
Enrollment : 500 participants
Observational Model: Defined Population
Time Perspective: Prospective
Study Start Date : March 2004
Study Completion Date : August 2004

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 6 Years   (Child)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Initial BLLs 100-440µg/L
  • Age 3-6y
  • No more than two main residences
  • House cleaned (no lead contaminated)
  • Normal intake history and physical

Exclusion Criteria:

  • Chelation in the past 12 weeks
  • Concomitant Fe deficiency(ferritin<16ng/ml)
  • Hemoglobin<10.5g/dL
  • Medications affecting mineral metabolism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00374894

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China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001
Sponsors and Collaborators
China Medical University, China
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Study Director: Jin Ya ping, professor Department of Environmental and Occupational Health
Publications of Results:
CDC.Preventing lead poisoning in young children[R]. U.D.Dept of health and Human services 1991:1.

Layout table for additonal information Identifier: NCT00374894    
Other Study ID Numbers: 20032063 - 2001102049
First Posted: September 12, 2006    Key Record Dates
Last Update Posted: September 12, 2006
Last Verified: April 2004
Keywords provided by China Medical University, China:
2,3-dimercaptosuccinic acid
Blood Lead Levels
Additional relevant MeSH terms:
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Lead Poisoning
Chemically-Induced Disorders
Heavy Metal Poisoning
Protective Agents
Physiological Effects of Drugs
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action