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Trial record 41 of 180 for:    ERYTHROMYCIN

The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00373919
Recruitment Status : Unknown
Verified August 2006 by Kaplan Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : September 8, 2006
Last Update Posted : March 5, 2007
Sponsor:
Information provided by:
Kaplan Medical Center

Brief Summary:

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy.

Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.

Design: This is a prospective, randomized, double blind, placebo controlled study.

Number of patients: 30.

Inclusion Criteria:

  • Patients after trans-hiatal esophagectomy

Exclusion Criteria:

  • Allergy to erythromycin
  • Use of phenothiazine
  • QT prolongation
  • Liver function test (LFT) abnormalities
  • Myasthenia gravis
  • Cardiomyopathy

Condition or disease Intervention/treatment Phase
Esophagectomy Postoperative Complications Drug: intravenous (IV) administration of erythromycin Not Applicable

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients after trans-hiatal esophagectomy

Exclusion Criteria:

  • Allergy to erythromycin
  • Use of phenothiazine
  • QT prolongation
  • Liver function test (LFT) abnormalities
  • Myasthenia gravis
  • Cardiomyopathy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00373919


Contacts
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Contact: Yoram Klein, MD 972-50-8213221 yoramkl@clalit.org.il

Sponsors and Collaborators
Kaplan Medical Center
Investigators
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Principal Investigator: Koram Klein, MD Kaplan Medical Center

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ClinicalTrials.gov Identifier: NCT00373919     History of Changes
Other Study ID Numbers: erythro-esophagus
First Posted: September 8, 2006    Key Record Dates
Last Update Posted: March 5, 2007
Last Verified: August 2006
Additional relevant MeSH terms:
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Erythromycin
Erythromycin Estolate
Erythromycin Ethylsuccinate
Erythromycin stearate
Postoperative Complications
Pathologic Processes
Anti-Bacterial Agents
Anti-Infective Agents
Gastrointestinal Agents
Protein Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action