Study of How Low Blood Sugar Affects the Way Blood Vessels Work
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|ClinicalTrials.gov Identifier: NCT00373854|
Recruitment Status : Completed
First Posted : September 8, 2006
Last Update Posted : June 8, 2016
Hypothesis: Low blood sugar (hypoglycemia) decreases function of the lining of the blood vessels in normal humans.
This study is designed to explore how hypoglycemia affects the function of the blood vessel lining. This will be determined by measuring blood flow to the arm before and after occlusion of flow. Blood vessel function will be measured before induction of hypoglycemia, during insulin induced hypoglycemia, and after recovery from hypoglycemia. A second study will be done but without hypoglycemia.
|Condition or disease|
Purpose: The purpose of the research is to learn more about how low blood sugar (low blood glucose or hypoglycemia) affects the way the blood vessels work in healthy people. Subjects who participate in this research project must be in good health and taking no medications.
Methods: A screening visit to the Clinical Research Center of the Ohio State University will be used to assess eligibility to participate. The main study consists of two visits to the Clinical Research Center that occur two to four weeks apart. Each of these visits will involve a procedure known as an insulin clamp. This involves giving insulin and sugar water into a vein. The amount of sugar given varies to keep the blood sugar at a predetermined level. For one of the two visits the blood sugar will be low and the other it will be normal. The function of the blood vessels will be measured three times during each study by measuring blood flow before and after stopping blood flow to the arm for 5 min.
|Study Type :||Observational|
|Actual Enrollment :||13 participants|
|Observational Model:||Case Control|
|Official Title:||Hypoglycemia and Endothelial Function|
|Study Start Date :||September 2005|
|Actual Primary Completion Date :||September 2006|
|Actual Study Completion Date :||September 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00373854
|United States, Ohio|
|Ohio State University|
|Columbus, Ohio, United States, 43210|
|Study Chair:||Robert P Hoffman, MD||Ohio State University|