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Optimal Treatment Frequency of 308-Nm Excimer Laser for Vitiligo on the Face and Neck

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00368407
Recruitment Status : Completed
First Posted : August 24, 2006
Last Update Posted : August 24, 2006
Information provided by:
Fourth Military Medical University

Brief Summary:

To determine the optimal treatment frequency of 308-nm excimer laser for vitiligo and identify the key clinical variable(s) associated with the treatment efficiency under the optimal treatment frequency.

Prospective, randomized, comparative study among groups of vitiligo patients treated with 308-nm excimer laser, with the limitation of no follow-up.

Condition or disease Intervention/treatment
Vitiligo Device: 308-nm excimer laser

Detailed Description:
Vitiligo patients were treated with 308-nm excimer laser for 20 sessions at different frequencies (0.5×, 1.0×, 2.0× and 3.0× weekly). Treatment protocols adapted the dose to the lesions and not to the minimal erythemal dose. Treatment efficacy was blindly evaluated by 2 independent physicians. Re-pigmentation rate was graded on a 6-point scale. The onset of re-pigmentation of vitiligo lesions was evaluated after 5 treatment sessions. The differences between Group 0.5×, 1.0×, 2.0× and 3.0× linking different clinical variables were assessed.

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Study Type : Observational
Allocation: Random Sample
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Optimal Treatment Frequency of 308-Nm Excimer Laser for Vitiligo on the Face and Neck
Study Start Date : April 2005
Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitiligo

Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • older than 2 years, stable vitiliginous patches during the past 3 months with surfaces of at least 4cm2, and an understanding of all information given by signing a written consent form.

Exclusion Criteria:

  • pregnant or breastfeeding women; personal history of a hypertrophic scar, skin cancer; taking immunosuppressive or photosensitizing drugs and undergoing phototherapy during the past 3 months.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00368407

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Department of dermatology, Xijing Hospital
Xi'an, SHANNXI, China, 710032
Sponsors and Collaborators
Fourth Military Medical University
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Study Director: gao tianwen, MD,PHD Ddepartment of Dermatology

Publications of Results:
Layout table for additonal information Identifier: NCT00368407     History of Changes
Other Study ID Numbers: fmmu200504
First Posted: August 24, 2006    Key Record Dates
Last Update Posted: August 24, 2006
Last Verified: April 2005

Keywords provided by Fourth Military Medical University:
308-nm excimer laser

Additional relevant MeSH terms:
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Pigmentation Disorders
Skin Diseases