Working… Menu
Trial record 43 of 231 for:    CALCITONIN SALMON

Functional MRI (fMRI) in CGRP Induced Migraine

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00363532
Recruitment Status : Completed
First Posted : August 15, 2006
Last Update Posted : January 28, 2009
Information provided by:
Danish Headache Center

Brief Summary:

In patients known with migraine without aura a migraine headache or migraine like headache will be induced by infusion of calcitonin gene related peptide (CGRP). The patients will then be stimulated with noxious heat via a thermode placed at the forehead. At the same time the Blood-oxygenation-level-dependent (BOLD) response will be measured via functional magnetic resonance imaging (fMRI), to estimate the central-nervous pain response. The regions of interest (ROI) will be thalamic region and medulla oblongata.

Then the patients will be given pain relif in form of injection of sumatriptan and the effect of this will also be registered via measuring the BOLD response at the RIO's previously defined. A 3-Tesla MRI scanner will be used in this trail.

This study will give us key knowledge of the trigeminal pain pathway and the central processing i.e sensitization during a migraine attach.

Condition or disease Intervention/treatment Phase
Migraine Without Aura Drug: infusion of calcitonin gene related peptide (CGRP) Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Functional MRI (fMRI) in Patients With Migraine Without Aura Provoked by
Study Start Date : September 2006
Actual Primary Completion Date : July 2007
Actual Study Completion Date : July 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Headache Migraine
Drug Information available for: Calcitonin

Primary Outcome Measures :
  1. Changes in BOLD response before and after CGRP infusion.
  2. Changes in BOLD response before and after injection of sumatriptan.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients know with migraine without aura.
  • No less then 1 migraine attach pr month and no more then 6 attaches per month.
  • Weight 50-100 kg.
  • Women must be using secure birthcontrol.

Exclusion Criteria:

  • Tension type headache more then 1 day/month.
  • All other prim. og sec. headache types then migraine without aura.
  • Daily use of medication other then birthcontrol pills.
  • Pregnant and lactation women.
  • Headache on the trail day or 5 days previous to the trail day.
  • Contraindications to MRI-scans.
  • Hypertension or hypotension.
  • Known heart or lung condition.
  • Mental illness or substance abuse.
  • Other considerable conditions judged by the including doctor.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00363532

Layout table for location information
Danish Headache Center, Neurological Dep. Glostrup hospital
Glostrup, Denmark, 2770
Sponsors and Collaborators
Danish Headache Center
Layout table for investigator information
Study Chair: Messoud Ashina, MD,PH.d Danish Headache Center

Layout table for additonal information
Responsible Party: Mohammad Sohail Asghar, MD, Neurological Dep. University of Copenhagen, Denmark, Glostrup Hospital. Identifier: NCT00363532     History of Changes
Other Study ID Numbers: KA-20060083
First Posted: August 15, 2006    Key Record Dates
Last Update Posted: January 28, 2009
Last Verified: January 2009
Keywords provided by Danish Headache Center:
migraine with out aura
Additional relevant MeSH terms:
Layout table for MeSH terms
Calcitonin Gene-Related Peptide
Migraine Disorders
Migraine without Aura
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Calcium-Regulating Hormones and Agents
Physiological Effects of Drugs
Bone Density Conservation Agents
Vasodilator Agents