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Trial record 100 of 326 for:    clonidine

The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00356226
Recruitment Status : Completed
First Posted : July 25, 2006
Last Update Posted : December 4, 2006
Information provided by:
CHU de Charleroi

Brief Summary:
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.

Condition or disease Intervention/treatment Phase
Ascitic Cirrhosis Hyperactivation of Sympathetic Nervous System Drug: clonidine Not Applicable

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Study Type : Interventional  (Clinical Trial)
Enrollment : 64 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.
Study Start Date : October 2000

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Cirrhotic patients with ascites
  • Plasma norepinephrine level > 300 pg/mL (normal value: 185 – 275 pg/mL)

Exclusion Criteria:

  • Serum bilirubin concentration above 4.5 mg/dL
  • Prothrombin time below 40%
  • Platelet count below 40 X 10¨9/liter
  • Serum creatinine concentration above 2 mg/dL
  • Gastro-intestinal hemorrhage
  • Alcoholic hepatitis
  • Diabetes mellitus,
  • Hepatocellular carcinoma
  • Respiratory or cardiac failures
  • Hepatic encephalopathy
  • Bacterial infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00356226

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ISPPC CHU de Charleroi
Charleroi, Belgium, 6000
Sponsors and Collaborators
CHU de Charleroi
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Principal Investigator: Lenaerts Anne, MD ISPPC CHU de Charleroi

Publications of Results:
Other Publications:
Layout table for additonal information Identifier: NCT00356226     History of Changes
Other Study ID Numbers: HEP-05-1550.R2
First Posted: July 25, 2006    Key Record Dates
Last Update Posted: December 4, 2006
Last Verified: October 2000
Keywords provided by CHU de Charleroi:
Additional relevant MeSH terms:
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Pathologic Processes
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Antihypertensive Agents
Autonomic Agents
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents