COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Arterial Stiffness, Wave Reflections and Renal Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00354588
Recruitment Status : Completed
First Posted : July 20, 2006
Last Update Posted : November 4, 2010
Information provided by:
Klinikum Wels-Grieskirchen

Brief Summary:
  1. Cardiovascular risk is high in patients with renal failure.
  2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature.
  3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available.
  4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure

Condition or disease
Chronic Renal Failure Arterial Stiffness Arterial Wave Reflections

Layout table for study information
Study Type : Observational
Actual Enrollment : 115 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study on the Prognostic Significance (Renal and Cardiovascular) of Arterial Stiffness and Arterial Wave Reflections in Patients With Mild to Moderate Renal Impairment
Study Start Date : January 2006
Actual Primary Completion Date : October 2010
Actual Study Completion Date : October 2010

Primary Outcome Measures :
  1. renal endpoint
    doubling serum creatinine, need for dialysis, renal transplantation

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   19 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with chronic renal failure

Inclusion Criteria:

  • chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department
  • > 19 years
  • written informed consent

Exclusion Criteria:

  • atrial fibrillation
  • valvular heart disease
  • severely impaired systolic function
  • no informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00354588

Layout table for location information
Cardiology and Nephrology Department Klinikum Wels
Wels, Austria, 4600
Sponsors and Collaborators
Klinikum Wels-Grieskirchen
Layout table for investigator information
Principal Investigator: Thomas Weber, MD Cardiology Department, Klinikum Wels, Austria
Principal Investigator: Manfred Wallner, MD Nephrology Department, Klinikum Wels, Austria
Layout table for additonal information
Responsible Party: Thomas Weber, MD, Klinikum Wels-Grieskirchen Identifier: NCT00354588    
Other Study ID Numbers: WelsEK 206
First Posted: July 20, 2006    Key Record Dates
Last Update Posted: November 4, 2010
Last Verified: November 2010
Keywords provided by Klinikum Wels-Grieskirchen:
chronic renal failure
arterial stiffness
arterial wave reflections
Additional relevant MeSH terms:
Layout table for MeSH terms
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic