Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass?
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ClinicalTrials.gov Identifier: NCT00350441
Recruitment Status : Unknown
Verified July 2006 by NHS Greater Glasgow Yorkhill Division. Recruitment status was: Recruiting
Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease.
A Randomised, Double-Blind, Placebo-Controlled, Single-Centre Study of the Pre-Operative Effect of Sildenafil Citrate on Pulmonary Related Complications Following Cardiopulmonary Bypass in Children Undergoing Cardiac Surgical Repair.
Study Start Date :
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Layout table for eligibility information
Ages Eligible for Study:
3 Months to 5 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Paediatric patients undergoing open heart surgery utilising cardiopulmonary bypass to correct acyanotic congenital heart disease.
Age > 3 months Parents that show a good understanding of their child's condition and are happy for their child to participate in the study.
Patients with known organ dysfunction prior to surgery (pulmonary, renal or hepatic) Communication barrier resulting in poor basic comprehension of the proposed study (e.g. language barrier) Patients with cyanotic heart disease Patients undergoing heart surgery without the use of cardiopulmonary bypass Patients who do not tolerate oral Sildenafil (e.g. Vomiting) or whose surgery is subsequently cancelled.