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Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia

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ClinicalTrials.gov Identifier: NCT00349323
Recruitment Status : Completed
First Posted : July 7, 2006
Last Update Posted : May 8, 2008
Sponsor:
Collaborators:
Department of Community Medicine & Department of Biological Sciences
University of Zambia
Information provided by:
DBL -Institute for Health Research and Development

Brief Summary:

The WHO Special Programme for Research and Training in Tropical Diseases (TDR) developed a Community-Directed Treatment (COMDT) approach, which has been adopted in the control of onchocerciasis and lymphatic filariasis. WHO has recommended the use of COMDT approach in the control of schistosomiasis and STH infections. The COMDT approach has been compared with the school based programmes in certain African countries,but not with the health-facility based approach.

The project will be implemented in Mazabuka district of Zambia where COMDT approach will be implemented in the catchment area of Rural Health Centres (RHC) as a supplement to the health-facility-based approach. After each round of treatmenttreatment coverage and factors responsible for the treatment coverage will be measured in both areas. The health impact of the health facility based approach with and without the COMDT approach will be compared. The effect of the COMDT as a control approach of STH infections will be monitored on infections in the community of children aged 12 to 59 months.


Condition or disease Intervention/treatment
Soil-Transmitted Helminth Infection Growth Behavioral: Community directed treatment

Detailed Description:

Soil-transmitted helminth (STH) infections are of public health importance and widespread in large part of the world, particularly in the poorest sections of the populations residing in the least developed countries. The infections can be controlled by several measures, but currently delivering anthelminthic drugs through schools and health centres is believed to be the most effective as it takes advantage of existing infrastructure. In Zambia, anthelminthic drugs are delivered to children aged 12 to 59 months twice a year through health facilities during the child health promotion week. However, it has been observed that treatment coverage is low in certain areas. Therefore, there is a need to identify the factors associated with the treatment coverage patterns, and to provide evidence of an effective intervention approach that could increase the proportion of children receiving treatment.

The WHO Special Programme for Research and Training in Tropical Diseases (TDR) developed a Community-Directed Treatment (COMDT) approach, which has been adopted in the control of onchocerciasis and lymphatic filariasis. WHO has recommended the use of COMDT approach in the control of schistosomiasis and STH infections. The COMDT approach has been compared with the school based programmes in certain African countries, but has never been used in Zambia and never been compared with the health-facility based approach in the control of these infections in children below school age. It is against this background that this project is being proposed.

The project will be implemented in Mazabuka district of Zambia. Two Rural Health Centres (RHCs) will be selected in the district and mapped for treatment coverage of the health-facility based approach. Focus group discussions (FGDs) and in-depth interviews will be conducted with community members to explore the reasons for existing treatment coverage of the health facility approach. The COMDT approach will then be implemented in the catchment area of one of the RHCs as a supplement to the health-facility-based approach. After each round of treatment, coverage and factors influencing coverage will be measured in both areas. The health impact of the health facility based approach with and without the COMDT approach will be compared. Parameters for health impact will be child growth, prevalence and intensity of STH infections and number of illness episodes requiring treatment. The effect of the COMDT as a control approach of STH infections will be monitored on infections in the community of children aged 12 to 59 months, and the appropriateness of the approach will be evaluated using the African Programme for Onchocerciasis Control grading system. The whole project is expected to take 3 years.

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Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Official Title: Community-Directed Treatment in the Control of Soil-Transmitted Helminths Among Children Aged 12-59 Months in Mazabuka District of Zambia
Study Start Date : August 2006
Actual Primary Completion Date : August 2007
Actual Study Completion Date : September 2007

Resource links provided by the National Library of Medicine






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Ages Eligible for Study:   12 Months to 59 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age 12-59 months

Exclusion Criteria:

  • Severely ill children

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00349323


Locations
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Zambia
Mazabuka District
Mazabuka, Zambia
Sponsors and Collaborators
DBL -Institute for Health Research and Development
Department of Community Medicine & Department of Biological Sciences
University of Zambia
Investigators
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Principal Investigator: Hikabasa Halwindi, M.phil Department of Community Medicine, University of Zambia

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT00349323    
Other Study ID Numbers: 2006-7041-83/hah
First Posted: July 7, 2006    Key Record Dates
Last Update Posted: May 8, 2008
Last Verified: February 2008
Keywords provided by DBL -Institute for Health Research and Development:
Community directed treatment,
soil-transmitted helminth infections,
treatment coverage,
Zambia
Additional relevant MeSH terms:
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Helminthiasis
Parasitic Diseases