Analysis of the Immune Response to the Malaria Parasite in Mali, West Africa
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|ClinicalTrials.gov Identifier: NCT00346346|
Recruitment Status : Completed
First Posted : June 29, 2006
Last Update Posted : May 8, 2019
This study will examine the immune response to the malaria parasite at the cellular level to better understand why people achieve natural immunity to the parasite only after multiple infections and why immunity diminishes rapidly in the absence of ongoing infection. The results of this study may provide insight into whether and how natural immunity can be improved upon by vaccination.
Healthy people 2-4 and 18-25 years of age who live in the village of Kambila, Mali, may be eligible for this 1-year study. Participants have a small blood sample collected from a vein in the arm and also from two finger pricks at the beginning of the study, then every 2 months for 6 months and at the end of the study (for a total of five samples). People who become ill with malaria are evaluated and treated by a physician. Those recovering from their first episode of malaria during the study period have another blood sample collection and two finger pricks (bringing to six the total number of samples collected).
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||237 participants|
|Official Title:||Longitudinal Analysis of the B-Cell Immune Response to Plasmodium Falciparum in Mali|
|Study Start Date :||April 17, 2006|
|Study Completion Date :||January 23, 2013|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00346346
|Malaria Research and Training Center|
|Principal Investigator:||Peter D Crompton, M.D.||National Institute of Allergy and Infectious Diseases (NIAID)|