Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
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|ClinicalTrials.gov Identifier: NCT00342992|
Recruitment Status : Completed
First Posted : June 21, 2006
Last Update Posted : September 9, 2020
The project is a passive follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort. Originally, this was a large, randomized, double-blind, placebo-controlled, 2x2 factorial primary prevention trial testing the effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality. The study was conducted in Finland as a collaboration between the U.S. National Cancer Institute (NCI) and the National Public Health Institute of Finland. NCI has maintained passive surveillance of the cohort through Finnish national registries, including the cancer registry.
The primary purpose of the ATBC cohort follow-up is to use the existing risk factor data and biological specimens (i.e., serum, whole blood, DNA, red blood cells, and toenails) to test hypotheses relevant to cancer etiology, survival, early detection, and prevention. These data and biospecimens continue to provide an invaluable resource for the study of biochemical, nutritional, genetic, and molecular hypotheses. These analyses are made all the more informative and powerful by the addition of cases identified annually during the follow-up period, and the research benefits from a longer pre-diagnosis period (now over 30 years).
|Condition or disease|
|Stroke Diabetes Mellitus Heart Disease Cancer|
|Study Type :||Observational|
|Actual Enrollment :||29133 participants|
|Official Title:||Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) Population|
|Actual Study Start Date :||March 3, 1995|
|Actual Primary Completion Date :||September 4, 2020|
|Actual Study Completion Date :||September 4, 2020|
Male smokers in Southwestern Finland
- Cancer [ Time Frame: Annually ]Annual linkage with Finnish Cancer Registry
- Causes of mortality [ Time Frame: Anually ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342992
|National Institute of Health and Welfare, Helsinki, Finland|
|Principal Investigator:||Demetrius A Albanes, M.D.||National Cancer Institute (NCI)|