The Incidence of Breast and Other Cancers Among Female Flight Attendants
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| ClinicalTrials.gov Identifier: NCT00342407 |
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Recruitment Status :
Completed
First Posted : June 21, 2006
Last Update Posted : April 10, 2020
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Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption form traveling across multiple time zones. This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related. The study will include a cohort of approximately 10,000 women who were employed as flight attendants for one or more years.
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects, as well as from death certificates. The interview will also provide information about non-occupational risk factors for breast cancer such as parity. Both internal and external comparisons will be made. The primary analysis will evaluate the risk associated with occupational exposure within the cohort, controlling for non-occupational risk factors by stratification or modeling. The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population, with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption. The risk of other ionizing radiation-related cancers, such as leukemia, lung cancer, and thyroid cancer, among flight attendants will also be evaluated. The results of the study will apply to female flight crew and frequent fliers.
| Condition or disease |
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| Thyroid Cancer Breast Cancer Non-Melanoma Skin Cancer Melanoma |
Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption from traveling across multiple time zones. This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related. The study will include a cohort of approximately 9,631 women who were employed as flight attendants for one or more years.
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects, as well as from death certificates. The interview will also provide information about non-occupational risk factors for breast cancer such as parity. Both internal and external comparisons will be made. The primary analysis will evaluate the risk associated with occupational exposure within the cohort, controlling for non-occupational risk factors by stratification or modeling. The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population, with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption. The risk of other ionizing radiation-related cancers, such as leukemia, lung cancer, and thyroid cancer, among flight attendants will also be evaluated. The results of the study will apply to female flight crew and frequent fliers.
| Study Type : | Observational |
| Actual Enrollment : | 6093 participants |
| Observational Model: | Case-Only |
| Time Perspective: | Other |
| Official Title: | The Incidence of Breast and Other Cancers Among Female Flight Attendants |
| Actual Study Start Date : | November 6, 2001 |
| Actual Primary Completion Date : | December 31, 2005 |
| Actual Study Completion Date : | April 9, 2020 |
| Group/Cohort |
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Cohort
Female flight attendants
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- Breast and other cancers [ Time Frame: Time of questionnaire, time of death ]survival
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| Ages Eligible for Study: | 18 Years to 100 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
- INCLUSION CRITERIA:
Employed as a flight attendant for one or more years by Pan AM before Pan Am ceased operation in 1991. For flight attendants who transferred to Pan Am from National Airlines when Pan Am bought National Airlines in 1981, the time employed as a flight attendant at National Airlines will be counted towards the one year minimum.
A U.S. citizen when they began working at Pan Am (or National Airlines, if the flight attendant transferred to Pan AM from National Airlines).
Worked at least one day after January 1, 1953.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342407
| United States, Ohio | |
| National Institute for Occupational Safety and Health (NIOSH) | |
| Cincinnati, Ohio, United States, 45226 | |
| Principal Investigator: | Mark P Little, Ph.D. | National Cancer Institute (NCI) |
| Responsible Party: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00342407 |
| Other Study ID Numbers: |
999902039 02-C-N039 |
| First Posted: | June 21, 2006 Key Record Dates |
| Last Update Posted: | April 10, 2020 |
| Last Verified: | April 2020 |
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Cancer Risk Cosmic Radiation Airlines Flight Attendants Circadian Rhythm |
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Thyroid Neoplasms Skin Neoplasms Neoplasms Endocrine Gland Neoplasms Neoplasms by Site |
Head and Neck Neoplasms Endocrine System Diseases Thyroid Diseases Skin Diseases |