Diet and Genetic Damage
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00340743|
Recruitment Status : Completed
First Posted : June 21, 2006
Last Update Posted : October 19, 2017
This study will examine the risks and protective effects of dietary factors on temporary genetic damage to cells lining the gastrointestinal tract and to blood cells. Some foods, including very well done meat, may increase genetic damage in cells, while others, such as yogurt and vegetables, may reduce genetic damage. This study may provide new information on the influence of diet on increasing or decreasing the risk of developing cancer, particularly colorectal cancer. The study is conducted at the General Clinical Research Center (GCRC) of the University of North Carolina.
Nonsmoking, English-speaking, healthy adults between 18 and 45 years of age may be eligible for this 4-week study. Participants undergo the following tests and procedures:
- Interview: Participants complete questionnaires including information on their diets, habits, past and present health, and family histories.
- Diet: Participants adhere strictly to the diet provided by the dietician at the GCRC for all 4 weeks of the study. All meals are provided by the GCRC. All meals contain well-done meat and some contain yogurt, cruciferous vegetables, including broccoli and cabbage, and chlorophyllin tablets. Chlorophyllin is a compound in some foods that protects against genetic damage.
- Urine sampling: Participants collect a urine sample each morning except Saturday and Sunday.
- Stool sampling: Participants collect two stool samples during the study, one during the second week and another during the fourth week.
- Blood draw: About 2-1/2 tablespoons of blood are drawn once a week for research purposes. The blood is tested for the effects of eating foods in the different diets used in the study.
- Rectal biopsies: Four pinch biopsies, each about the size of a grain of rice, are taken from the rectum once a week for research purposes. For this procedure, forceps are inserted shallowly into the rectum to collect the tissue. The effects of the different diets on the colon cells are measured.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||16 participants|
|Official Title:||Inhibition of Fried Meat-Induced DNA Damage: A Dietary Intervention Study|
|Study Start Date :||April 21, 2004|
- to determine if eating certain foods and other dietary constituents will ameliorate the short-term damaging effects associated with fried meat consumption. [ Time Frame: Continuously ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00340743
|United States, North Carolina|
|University of North Carolina|
|Chapel Hill, North Carolina, United States, 27599-7030|
|Principal Investigator:||Jack Taylor, M.D.||National Institute of Environmental Health Sciences (NIEHS)|