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Lantus Effect on Myocardial Glucose Metabolism in T2

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ClinicalTrials.gov Identifier: NCT00335465
Recruitment Status : Completed
First Posted : June 9, 2006
Last Update Posted : December 7, 2009
Sponsor:
Information provided by:
Sanofi

Brief Summary:

The primary objective of the present study is to assess changes of myocardial glucose uptake (MGU) during clamp studies using positron emission tomography (PET) scanning in patients with type 2 diabetes and idiopathic left ventricular dysfunction (LVD).

The secondary objectives of the study are: assessment of changes of myocardial microcirculation at rest and during adenosine stimulation using PET; assessment of changes in myocardial structure and function evaluated by magnetic resonance imaging (MRI); assessment of glycaemic control by measurement of HbA1c, fasting blood glucose and insulin levels; assessment of safety (adverse event profile, laboratory data).


Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Drug: Insulin glargine Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Pilot Study for the Evaluation of the Effects of Insulin Treatment on Myocardial Function, Perfusion, and Glucose Metabolism in Patients With Primary Left Ventricular Dysfunction and Type 2 Diabetes.
Study Start Date : September 2005
Actual Primary Completion Date : June 2008
Actual Study Completion Date : June 2008

Resource links provided by the National Library of Medicine



Intervention Details:
  • Drug: Insulin glargine
    once a daily, sc injection, 100IU/ml


Primary Outcome Measures :
  1. effect of insulin treatment on myocardial function, perfusion and glucose metabolism. [ Time Frame: assessed before and after treatment ]
  2. adverse events [ Time Frame: throughout the study ]

Secondary Outcome Measures :
  1. changes of myocardial structure and left ventricular systolic and diastolic function [ Time Frame: at baseline and at the end of the study ]


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • LV systolic dysfunction (2D-Echo LVEF < 50%) with or without LV dilation (2D-Echo LV EDD > 56 mm) or left ventricular end-diastolic diameter (LVEDD) >55mm with or without LV dysfunction
  • angiographically normal coronary arteries (< 50% vessel narrowing);
  • newly diagnosed type 2 diabetes;
  • previously diagnosed: OAD treated type 2 diabetic patients able to take part in the study after a one-month wash-out period and insulin treated type 2 diabetic patients able to take part in the study after one week wash-out period.

Exclusion Criteria:

  • evidence of congenital or valvular cardiac diseases, hypertrophic cardiomyopathy, overt heart failure (NYHA class III-IV);
  • moderate to severe hypertension (diastolic aortic pressure > 100 mmHg);
  • hypotension (systolic aortic pressure < 100 mmHg);
  • nephropathy (serum creatinine > 3 mg/dL);
  • other systemic and/or infective diseases;
  • severe dyslipidemia;
  • peripheral vasculopathy;
  • necessity of vasoactive medical treatment in the last 48 hours;
  • atrial fibrillation;
  • Refusal or impossibility to give written informed consent;
  • patients diagnosed with type 1 insulin dependent diabetes;
  • clinically relevant cardiovascular, hepatic, endocrine, or other major systemic disease making implementation of the protocol or interpretation of the study results difficult;
  • patients with medical history positive for cerebrovascular accidents, including Transient Ischaemic Attack (TIA);
  • women who are lactating, pregnant, or planning to become pregnant during the study;
  • history of hypersensitivity to the investigational products or to drugs with similar chemical structures;
  • likelihood of requiring treatment during the study period with drugs not permitted by the clinical study protocol;
  • treatment with any investigational product in the last 30 days or 5 half-lives (whichever is longer) before study entry;
  • current use of investigational agents or participation in any other investigational studies during study period;
  • history of drug or alcohol abuse;
  • impaired hepatic function, as shown by Alamine AminoTransferase (ALT) > 2,5 times the upper limit of the normal laboratory range;
  • mental condition making the subject unable to understand the nature, scope, and possible consequences of the study;
  • patients unable to understand dosing directions;
  • subject unlikely to comply with protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study procedures;
  • receipt of an experimental drug or use of an experimental device within the 30 days prior to study entry;
  • previous enrollment in the present study.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00335465


Locations
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Italy
Sanofi-Aventis Administrative Office
Milan, Italy
Sponsors and Collaborators
Sanofi
Investigators
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Study Director: Georges Paizis, MD Sanofi

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Medical Affairs Study Director, sanofi-aventis
ClinicalTrials.gov Identifier: NCT00335465     History of Changes
Other Study ID Numbers: HOE901_4053
EUDRACT # : 2004-002729-34
First Posted: June 9, 2006    Key Record Dates
Last Update Posted: December 7, 2009
Last Verified: December 2009

Additional relevant MeSH terms:
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Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin
Insulin Glargine
Hypoglycemic Agents
Physiological Effects of Drugs