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Cognitive Remediation in Early Substance Abuse Treatment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00334217
Recruitment Status : Terminated (The intervention could not be successfully carried out in the SADP setting because of issues independent of the cognitive training intervention.)
First Posted : June 6, 2006
Last Update Posted : June 18, 2009
Information provided by:
VA Office of Research and Development

Brief Summary:
This study is for the purpose of determining whether cognitive remediation may improve cognition and treatment response in patients entering substance abuse day treatment

Condition or disease Intervention/treatment Phase
Substance-Related Disorders Behavioral: Cognitive Remediation Not Applicable

Detailed Description:

Background: Patients entering substance abuse treatment display cognitive deficits that may reduce their ability to benefit from their treatment. While there is considerable variety in the severity and types of cognitive impairment found in newly recovering patients, problems with attention, memory and executive function are very common. Since treatment requires sustained attention, remembering what is learned, integrating that knowledge and applying it to recovery, impairment in underlying cognitive processes makes successful treatment less likely. Although cognitive functioning improves with sustained sobriety, it is during the early phase of recovery that most patients receive the most intensive treatment. Recent research has suggested that cognitive remediation exercises during this early phase may speed up the return of cognitive functioning and in so doing may have a direct effect on whether patients find the treatment useful and complete their treatment. By keeping patients in treatment longer, cognitive remediation may have an indirect effect on substance abuse outcomes.

Objectives: To pilot test the introduction of cognitive remediation at the Substance Abuse Day Treatment Program (SADP) at the Errara Community Care Center. Aims are 1) to assess the receptivity of patients to the intervention by determining rates of agreement to participate, 2) to determine the number of cognitive remediation sessions that patients are willing to engage in, 3) to assess a variety of cognitive remediation tasks for their acceptability, 4) to evaluate neuropsychological improvements using pre-post assessment, 5) to evaluate its effects on substance abuse treatment participation, and 6) to evaluate its effects on substance abuse outcomes at 6 months follow-up.

Design: Randomized clinical trial of cognitive remediation with an active control condition with observations at baseline, end of treatment and 6-months from intake

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cognitive Remediation in the Initial Phase of Substance Abuse Treatment: Feasibility and Efficacy
Study Start Date : August 2005
Actual Primary Completion Date : August 2007
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Drug Abuse

Arm Intervention/treatment
Experimental: 1
PSS CogRehab exercises
Behavioral: Cognitive Remediation
PSS Cogrehab

No Intervention: 2
On-line computer games

Primary Outcome Measures :
  1. Cognitive improvement and adherence to substance abuse treatment [ Time Frame: 6 month follow-up ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Veterans participating in a substance abuse day treatment program at the Errara Community Center

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00334217

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United States, Connecticut
VA Connecticut Health Care System (West Haven)
West Haven, Connecticut, United States, 06516
Sponsors and Collaborators
US Department of Veterans Affairs
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Principal Investigator: Morris D Bell, PhD VA Connecticut Health Care System (West Haven)
Publications of Results:
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Responsible Party: Bell, Morris - Principal Investigator, Department of Veterans Affairs Identifier: NCT00334217    
Other Study ID Numbers: O3108R
First Posted: June 6, 2006    Key Record Dates
Last Update Posted: June 18, 2009
Last Verified: June 2009
Keywords provided by VA Office of Research and Development:
Psychology: cognitive aspects
Substance-Related Disorders
treatment efficacy
Additional relevant MeSH terms:
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Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders