Hypertension Related Damage to the Microcirculation in South Asian: Emergence, Predictive Power and Reversibility
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|ClinicalTrials.gov Identifier: NCT00331370|
Recruitment Status : Unknown
Verified May 2006 by Aga Khan University.
Recruitment status was: Not yet recruiting
First Posted : May 31, 2006
Last Update Posted : May 31, 2006
|Condition or disease||Intervention/treatment||Phase|
|Hypertension Diabetes Cardiovascular Disease Retinopathy||Behavioral: GP training and Health Education||Not Applicable|
The role of the microcirculation is increasingly being recognized in the etiopathogenesis of cardiovascular disease. Delays in this recognition are in part due to the difficulty of studying the microcirculation non-invasively, in large numbers of individuals. Retinal vessels provide an easily accessible "window" to the microcirculation. Abnormalities of the retinal vasculature have been shown to be associated with cardiovascular risk factors and all cause mortality. Non-invasive assessment of the retinal circulation presents a valuable opportunity to study the structure and function of the microvasculature
Aims of the project
To compare geometry of retinal microvasculature of 1) hypertensive vs normotensive adults, 2) children aged 10 to 14 years of hypertensive parent (test group) versus normotensive parent (control group), and, 3) to assess the impact of blood pressure lowering on these changes over 2 years.
Primary outcome would be abnormal retinal geometry defined as the composite outcome of a) abnormal arteriolar length: diameter ratios (a measure of relative arteriolar narrowing), b) narrowed branching angles (an indicator of arteriolar rarefaction), or c) disturbed junction exponents (a marker of endothelial dysfunction.
Significance of the study
If successful, this work could be extended to address future questions, including the predictive value of these abnormalities for development of diabetes and hypertension as well as CVD; to explore further the role of microvascular disturbances in disease etiology, and to assess the impact of drug therapy on these abnormalities and their relationship to outcomes in the South Asian population
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||2880 participants|
|Intervention Model:||Factorial Assignment|
|Official Title:||Hypertension Related Damage to the Microcirculation in South Asian: Emergence,Predictive Power and Reversibility|
|Study Start Date :||May 2006|
|Study Completion Date :||June 2009|
- Primary outcome would be abnormal retinal geometry defined as the composite outcome of a) abnormal arteriolar length: diameter, b) narrowed branching angles, or c) disturbed junction exponents.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00331370
|Contact: Tazeen H Jafar, Md,MPH||0092-4930051 ext firstname.lastname@example.org|
|Contact: Muhamamd Saleem Khan, MSc Epi&Bio||0092-4930051 ext email@example.com|
|Principal Investigator:||Tazeen H Jafar, MD, MPH||Aga Khan University|
|Study Chair:||Nish Chaturvedi, MD, MFPHM||Imperial College London|
|Study Chair:||Alun Hughes, MD, Phd||Imperial College London|
|Study Chair:||Juanita Hatcher, Phd, MSc||Aga Khan University|
|Study Chair:||Simon Thom, MD, FRCP||Imperial College London|
|Study Chair:||Khabir Ahmad, MD, MSc||Aga Khan University|
|Study Chair:||Muhammad Saleem Khan, MSc Epi&Bio||Aga Khan University|