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A Methodology Study To Look At Genes In Lung Cells And Tissue From Asthmatic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00331292
Recruitment Status : Terminated
First Posted : May 29, 2006
Last Update Posted : October 16, 2008
Sponsor:
Information provided by:
GlaxoSmithKline

Study Description
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Brief Summary:
The primary goal of this study is to identify a gene or panel of genes which are differentially expressed in lung cells and tissue from asthmatic patients following administration of Ipratropium bromide and eiTher nebulised Albuterol or saline. Each subject in this study will undergo two bronchoscopies.

Condition or disease
Asthma

Study Design
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Study Type : Observational
Enrollment : 30 participants
Time Perspective: Prospective
Official Title: A Study to Identify a Transcriptomic Profile Indicative of Cycle AMP Pathway Activation in the Lung
Study Start Date : August 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion criteria:

  • Have a history of intermittant asthma.
  • Have asthma symptoms less than once per week.
  • Have no other significant disease.
  • Do not take regular oral or inhaled steroids.
  • Are a non-smoker for the past 12 months with a pack history of less than 5 years.

Exclusion criteria:

  • Have a history of drug or alcohol abuse.
  • Have poorly controlled asthma or a history of life-threatening asthma.
  • Have a history of hypersensitivity to bronchodilators.
  • Are unable to abstain from inhaled steroids from 14 days prior to the first study visit until completion of the study.
  • Have received oral steroids within 3 months of study entry.
  • Have been hospitalized for your asthma within 3 months of study entry.
  • Have had treatment with an investigational drug within 30 days or 5 half-lives (whichever is longer) preceding the first dose of study medication.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00331292


Locations
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United States, Pennsylvania
GSK Investigational Site
Philadelphia, Pennsylvania, United States, 19104
Sponsors and Collaborators
GlaxoSmithKline
Investigators
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Study Director: GSK Clinical Trials, MD GlaxoSmithKline
More Information
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Responsible Party: Study Director, GSK
ClinicalTrials.gov Identifier: NCT00331292    
Other Study ID Numbers: CRB100706
First Posted: May 29, 2006    Key Record Dates
Last Update Posted: October 16, 2008
Last Verified: October 2008
Keywords provided by GlaxoSmithKline:
Asthma bronchoscopy
Additional relevant MeSH terms:
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Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
 Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases