Flavonoid Supplementation and Endothelial Function
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|ClinicalTrials.gov Identifier: NCT00331227|
Recruitment Status : Completed
First Posted : May 29, 2006
Last Update Posted : March 15, 2007
Flavonoids are one of the many classes of natural chemicals found in a variety of foods. People with the highest flavonoid blood levels have the lowest rates of coronary heart disease. This is considered one of the reasons why high fruit and vegetable consumption is associated with lower rates of heart disease, although it is not known if taking a flavonoid supplement provides the same protection as eating fruits and vegetables.
The purpose of this study is to determine if a particular flavonoid supplement, called Isotonix OPC-3, taken on a daily basis, will improve the function of arterial vessels. Arteries normally constrict after eating a high-fat meal. This study will examine the potential of the OPC-3 to lessen this constriction response. Approximately 25 people will be involved in this research project and participation will last for 10 weeks.
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Drug: Isotonix OPC-3 (flavonoid supplement)||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||25 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Effect of Supplemental Flavonoids on Endothelial Function, Lipids, and Markers of Inflammation|
|Study Start Date :||May 2006|
|Study Completion Date :||December 2006|
- Change in endothelial function from baseline
- Lipid profile
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00331227
|Principal Investigator:||Thomas Barringer, MD||Carolinas Medical Center|