Intravenous Lidocaine and Acute Rehabilitation
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ClinicalTrials.gov Identifier: NCT00330941 |
Recruitment Status :
Completed
First Posted : May 29, 2006
Last Update Posted : June 29, 2016
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Background: Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function. The investigators therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization.
Methods: Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg.kg-1 lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg-1.h-1 intraoperatively and 1.33 mg.kg-1.h-1 for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leucocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (median [25%-75% interquartile range] Saline vs Lidocaine groups) were analyzed using Mann-Whitney tests. P<0.05 was considered statistically significant.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Pain, Postoperative Opioid Consumption, Postoperative Postoperative Fatigue | Drug: lidocaine | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 45 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double |
Primary Purpose: | Prevention |
Official Title: | Intravenous Lidocaine Infusion Improves Outcome After Laparoscopic Colectomy |
Study Start Date : | January 2003 |
Study Completion Date : | December 2004 |

- Sevoflurane consumption
- Pain scores
- abdominal comfort
- fatigue scores
- bowel function
- hospital stay
- endocrine and metabolic responses

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Ages Eligible for Study: | up to 70 Years (Child, Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- ASA I-III
- non-malignant disease
Exclusion Criteria:
- greater than 70 years
- history of gastro-duodenal peptic ulcer or renal failure (contraindications to the use of nonsteroidal anti-inflammatory drug)
- hepatic insufficiency
- psychiatric disorder
- steroid treatment
- chronic treatment with opioid

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00330941
Belgium | |
CHU de Liège, University of Liège | |
Liege, Belgium, B-4000 |
Study Director: | Jean Joris, MD, PhD | Department of Anesthesia and Intensive Care Medicine, CHU de Liège, University of Liège, Belgium |
ClinicalTrials.gov Identifier: | NCT00330941 |
Other Study ID Numbers: |
Joris, Lidocaine Outcomes |
First Posted: | May 29, 2006 Key Record Dates |
Last Update Posted: | June 29, 2016 |
Last Verified: | June 2016 |
Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Lidocaine Anesthetics, Local Anesthetics Central Nervous System Depressants |
Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Anti-Arrhythmia Agents Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action |