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Hysteroscopic Monopolar and Bipolar Resection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00323999
Recruitment Status : Unknown
Verified May 2006 by Ullevaal University Hospital.
Recruitment status was:  Recruiting
First Posted : May 10, 2006
Last Update Posted : May 10, 2006
Information provided by:
Ullevaal University Hospital

Brief Summary:
The aim of the study is to evaluate bipolar equipment versus monopolar, and to see if there is any differences between the two types of bipolar equipment espescially regading both safety and effect.

Condition or disease Intervention/treatment Phase
Menorrhagia Fibroid Polyps Procedure: Hysteroscopic resection of fibroids, polyps and endometrium. Not Applicable

Detailed Description:
  • Trial design: A prospective randomised study with three arms, one arm with monopolar surgery and two different arms with bipolar surgery. Its a one center study.
  • Trial population: Pre-or perimenopausal women reffered to our clinic with bleeding disorders and were we plan to do endometrial resection. Patients with a bleeding disorder due to fibroids type 0 and 1 will be included and patients with polyps were endometrial resection is planned at the same time will also be included.
  • Preoperative selection: The fibroids will be mapped using transvaginal ultrasound according to the classification ESGE. Type 0 and 1 fibroids will be included. Diameter of the fibroid must not extend 4cm. The endometrium size double layer will be recorded. Uterine size anetrior /posterior diameter, longitudinal diameter (cavity; top fundal to isthmus) will be measured. Were polyps are included these will be measured; length and width. Higham score (PBAC), Se-hgb, Ferritin, FSH and Oestradiol will be documented at all visits. Menstrual pain will be documented due to a VAS-scale.
  • Treatment regimen:Randomisation in blocs of 20 between monopolar and two types of bipolar surgery.
  • Surgical Technique: The cervical canal will be dilated to Hegar 10 or 11 and a rigid resectoscope Ch. 26 is passed to the uterine cavity. Glycine 1,5% or Saline (Baxter) is infused to irrigate the uterine cavity (Iglesias technique) Automatic pressure cuff maintains an infusion pressure of 100mm Hg and suction 10-15mmHg is applied to the outflow tube in order to achieve a sufficient flow.Fibroids type 0 and 1 are resected in total if possible or flush to the plane of the uterine wall. The tissue chips are removed at intervals by currette and forceps. The operation will be performed by experienced surgeons.
  • Primary response variables: Safety is our primary response variable. Fluid absorption and lowering of Se-Sodium will be analysed. These parameters are the only objective parameters which can tell us about safety. Nausea will be reorded on a VAS-scale.

    • Secondary resonse variables: Operating time, tissue removed, easisness of operation, levels of vaginal bleeding measured by the methosd of Hgham(PBAC)before and at follow up.

After 6 month and one year we will look at secondary intervention like repeated resection or hysterectomy.

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Study Type : Interventional  (Clinical Trial)
Official Title: A Randomised Trial to Compare the Differences Between Monopolar Surgery (Loop Resection) With Glycine 1,5% and Bipolar Surgery With Saline (Olympus,Versapoint) on Hysteroscopic Surgery.
Study Start Date : December 2004
Study Completion Date : December 2007

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:-Pre-or perimenopausal women with a bleeding disorder with or without fibroids or polyps -

Exclusion Criteria:-Postmenopausal patient. Infertility. Additional condition requiring treatment detected during examination. Malignancy or atypical hyperplasia detected by histological examination.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00323999

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Contact: Anette Berg, MD +4795219282
Contact: Olav Istre, MD., PhD. +4741302221

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Gynaecological department Ullevaal University Hospital Recruiting
Oslo, Norway
Sponsors and Collaborators
Ullevaal University Hospital
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Principal Investigator: Olav Istre, MD., PhD. Department of Gynaecology, Ullevaal University Hospital, Oslo, Norway
Layout table for additonal information Identifier: NCT00323999    
Other Study ID Numbers: AB170262
First Posted: May 10, 2006    Key Record Dates
Last Update Posted: May 10, 2006
Last Verified: May 2006
Keywords provided by Ullevaal University Hospital:
Hysteroscopic resection
Additional relevant MeSH terms:
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Neoplasms, Muscle Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Uterine Hemorrhage
Uterine Diseases
Pathologic Processes
Menstruation Disturbances