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Tai-Chi-Chuan on Differentiation and Maturation of Dendritic Cells

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00322959
Recruitment Status : Completed
First Posted : May 8, 2006
Last Update Posted : September 22, 2008
Information provided by:
Mackay Memorial Hospital

Brief Summary:

Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control.

Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state.

In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.

Condition or disease

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Effect of Tai-Chi-Chuan on Differentiation and Maturation of Human Dendritic Cells
Study Start Date : August 2004
Actual Primary Completion Date : November 2006
Actual Study Completion Date : November 2006

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
TCC practitioner and Healthy subjects as controls

Inclusion Criteria:

  • Yang TCC practitioner who keep practicing at least 3 times a week for more than 3 years
  • Healthy subjects as controls

Exclusion Criteria:

  • Who have a history of significant cardiovascular, pulmonary, and musculoskeletal diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00322959

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Department of Medical Research, Mackay Memorial Hospital
Taipei, Taiwan, 104
Sponsors and Collaborators
Mackay Memorial Hospital
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Principal Investigator: Yu-Jen Chen, MD, PhD Mackay Memorial Hospital
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Responsible Party: Yu-Jen Chen, Mackay Memorial Hospital Identifier: NCT00322959    
Other Study ID Numbers: MMH-I-S-056
First Posted: May 8, 2006    Key Record Dates
Last Update Posted: September 22, 2008
Last Verified: September 2008
Keywords provided by Mackay Memorial Hospital:
dendritic cells