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Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00322933
Recruitment Status : Terminated
First Posted : May 8, 2006
Last Update Posted : October 26, 2006
Information provided by:
Ziekenhuis Netwerk Antwerpen (ZNA)

Brief Summary:

This multicentre SHARF4 (Stuivenberg Hospital Acute Renal Failure) study aims to investigate outcome in patients with acute renal failure (ARF), stratified according to severity of disease (SHARF score) and randomised to different treatment options.

All adult patients with a serum creatinine >2 mg/dl were included. Patients were stratified according to disease severity and those in need for RRT were randomised to intermittent (IRRT) or continuous renal replacement therapy (CRRT)

Condition or disease Intervention/treatment
Renal Insufficiency, Acute Renal Replacement Therapy Procedure: renal replacement therapy (intermittent or continuous)

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Study Type : Observational
Enrollment : 1628 participants
Observational Model: Defined Population
Time Perspective: Prospective
Official Title: Multicentre Randomised Trial of Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure
Study Start Date : April 2001
Study Completion Date : March 2005

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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • adults (>17 years)
  • having acute renal failure: serum creatinine > 2 mg/dl
  • being in need for chronic renal replacement therapy (the decision to treat conservatively or to start RRT was at the discretion of the attending physician, taking into account the rules of good clinical practice in this field)

Exclusion Criteria:

  • patients with known pre-existing chronic renal disease, defined as a serum creatinine above 1.5 mg/dl or with clearly reduced kidney size on ultrasound were excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00322933

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Robert Lins
Antwerp, Belgium, 2170
Sponsors and Collaborators
Ziekenhuis Netwerk Antwerpen (ZNA)
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Principal Investigator: Robert L Lins, MD PhD Ziekenhuis Netwerk Antwerpen (ZNA)
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00322933    
Other Study ID Numbers: SHARF4
First Posted: May 8, 2006    Key Record Dates
Last Update Posted: October 26, 2006
Last Verified: April 2005
Keywords provided by Ziekenhuis Netwerk Antwerpen (ZNA):
intermittent renal replacement therapy
continuous renal replacement therapy
acute renal failure
renal recovery
Additional relevant MeSH terms:
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Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases