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Prophylactic Effect of Memantine in Chronic Tension-Type Headache

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00315666
Recruitment Status : Completed
First Posted : April 19, 2006
Last Update Posted : February 20, 2009
Information provided by:
Danish Headache Center

Brief Summary:
The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Condition or disease Intervention/treatment Phase
Tension-Type Headache Drug: memantine Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Prophylactic Effect of Memantine in Chronic Tension-Type Headache
Study Start Date : May 2006
Actual Primary Completion Date : June 2007
Actual Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Headache

Primary Outcome Measures :
  1. Headache duration
  2. Headache intensity

Secondary Outcome Measures :
  1. Headache frequency
  2. The use of simple analgesics
  3. Side effects

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chronic tension-type headache
  • Normal urine pH

Exclusion Criteria:

  • More than 1 migraine attack/month
  • Other major illnesses
  • Overuse of medicine/alcohol
  • Women not using AC
  • Pregnant/breast-feeding women
  • Allergy to memantine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00315666

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Danish Headaches Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
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Principal Investigator: Lars Bendtsen, MD, PhD Danish Headaches Center, Dept. of Neurology, KAS Glostrup, DK-2600 Glostrup

Layout table for additonal information Identifier: NCT00315666    
Other Study ID Numbers: 2006-000060-82
First Posted: April 19, 2006    Key Record Dates
Last Update Posted: February 20, 2009
Last Verified: February 2009
Keywords provided by Danish Headache Center:
Chronic tension-type headache
Additional relevant MeSH terms:
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Tension-Type Headache
Neurologic Manifestations
Signs and Symptoms
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents