Treatment of Survivors After Botulism Outbreak
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|ClinicalTrials.gov Identifier: NCT00314080|
Recruitment Status : Completed
First Posted : April 12, 2006
Last Update Posted : October 24, 2008
Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure.
Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.
|Condition or disease||Intervention/treatment|
|Respiratory Failure Botulism||Drug: Botulinum AntiToxin Procedure: neuro-electrophysiologic study, repetitive nerve stimulation Procedure: Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure|
|Study Type :||Observational|
|Enrollment :||18 participants|
|Official Title:||An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure|
|Study Start Date :||March 2006|
|Study Completion Date :||April 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00314080
|Bangkok, Thailand, 10400|
|Principal Investigator:||Subsai Kongsaengdao, M.D.||Rajavithi Hospital|