Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension
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The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital
Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
Creatinine clearance between 30-59 ml/min
Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
Healthy volunteers, aged between 18 and 65, both men and women
Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs